Manganese neurotoxicity: a focus on the neonate.

Manganese neurotoxicity: a focus on the neonate. Research Abstract Details 

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Manganese neurotoxicity: a focus on the neonate. Abstract Text:

Keith M Erikson,Khristy Thompson,Judy Aschner,Michael Aschner,

Manganese (Mn) is an essential trace metal found in all tissues, and it is required for normal amino acid, lipid, protein, and carbohydrate metabolism. While Mn deficiency is extremely rare in humans, toxicity due to overexposure of Mn is more prevalent. The brain appears to be especially vulnerable. Mn neurotoxicity is most commonly associated with occupational exposure to aerosols or dusts that contain extremely high levels (>1-5 mg Mn/m(3)) of Mn, consumption of contaminated well water, or parenteral nutrition therapy in patients with liver disease or immature hepatic functioning such as the neonate. This review will focus primarily on the neurotoxicity of Mn in the neonate. We will discuss putative transporters of the metal in the neonatal brain and then focus on the implications of high Mn exposure to the neonate focusing on typical exposure modes (e.g., dietary and parenteral). Although Mn exposure via parenteral nutrition is uncommon in adults, in premature infants, it is more prevalent, so this mode of exposure becomes salient in this population. We will briefly review some of the mechanisms of Mn neurotoxicity and conclude with a discussion of ripe areas for research in this underreported area of neurotoxicity.

Manganese neurotoxicity: a focus on the neonate. Publishing Authors By Initials

KM Erikson,K Thompson,J Aschner,M Aschner,

For similar nervous system diseases: neurotoxicity syndromes research abstracts see: nervous system diseases: neurotoxicity syndromes research

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Manganese neurotoxicity: a focus on the neonate. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmacology & therapeutics

VOLUME: 113

Page Numbers: 369-77

Journal Abbreviation: Pharmacol. Ther.

ISSN: 0163-7258

DAY: 22

MONTH: 09

YEAR: 2006

Manganese neurotoxicity: a focus on the neonate. Information

Number of References: 123

LANGUAGE: eng

NlmUniqueID: 7905840

Manganese neurotoxicity: a focus on the neonate. Keywords Mesh Terms:

KEYWORDS: Neurotoxicity Syndromes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Manganese neurotoxicity: a focus on the neonate. Information

Substance Name: Manganese

Registry Number: 7439-96-5

Grant and Affiliation Information for Manganese neurotoxicity: a focus on the neonate.

AFFILIATION: Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC, USA. kmerikso@uncg.edu

Country: England

AGENCY: United States NIEHS

GRANT: R01 ES010563-01A1

ACRONYM: ES

MEDLINETA: Pharmacol Ther

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