Manganese-enhanced magnetic resonance microscopy of mineralization.

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Manganese-enhanced magnetic resonance microscopy of mineralization. Abstract Text:

Ingrid E Chesnick,Todor I Todorov,Jose A Centeno,Dale E Newbury,John A Small,Kimberlee Potter,Ingrid E Chesnick,Todor I Todorov,Jose A Centeno,Dale E Newbury,John A Small,Kimberlee Potter,

Paramagnetic manganese (II) can be employed as a calcium surrogate to sensitize magnetic resonance microscopy (MRM) to the processing of calcium during bone formation. At high doses, osteoblasts can take up sufficient quantities of manganese, resulting in marked changes in water proton T(1), T(2) and magnetization transfer ratio values compared to those for untreated cells. Accordingly, inductively coupled plasma mass spectrometry (ICP-MS) results confirm that the manganese content of treated cell pellets was 10-fold higher than that for untreated cell pellets. To establish that manganese is processed like calcium and deposited as bone, calvaria from the skull of embryonic chicks were grown in culture medium supplemented with 1 mM MnCl(2) and 3 mM CaCl(2). A banding pattern of high and low T(2) values, consistent with mineral deposits with high and low levels of manganese, was observed radiating from the calvarial ridge. The results of ICP-MS studies confirm that manganese-treated calvaria take up increasing amounts of manganese with time in culture. Finally, elemental mapping studies with electron probe microanalysis confirmed local variations in the manganese content of bone newly deposited on the calvarial surface. This is the first reported use of manganese-enhanced MRM to study the process whereby calcium is taken up by osteoblasts cells and deposited as bone.

Manganese-enhanced magnetic resonance microscopy of mineralization. Publishing Authors By Initials

IE Chesnick,TI Todorov,JA Centeno,DE Newbury,JA Small,K Potter,IE Chesnick,TI Todorov,JA Centeno,DE Newbury,JA Small,K Potter,

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Manganese-enhanced magnetic resonance microscopy of mineralization. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Magnetic resonance imaging

VOLUME: 25

Page Numbers: 1095-104

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ISSN: 0730-725X

DAY: 16

MONTH: 01

YEAR: 2007

Manganese-enhanced magnetic resonance microscopy of mineralization. Information

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LANGUAGE: eng

NlmUniqueID: 8214883

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Grant and Affiliation Information for Manganese-enhanced magnetic resonance microscopy of mineralization.

AFFILIATION: Magnetic Resonance Microscopy Facility, Department of Biophysics, Armed Forces Institute of Pathology Annex, Rockville, MD 20850, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR51446

ACRONYM: AR

MEDLINETA: Magn Reson Imaging

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