Management of polycystic liver disease.

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Management of polycystic liver disease. Abstract Text:

Gregory T Everson,Matthew R G Taylor,Gregory T Everson,Matthew R G Taylor,Gregory T Everson,Matthew R G Taylor,

The adult forms of polycystic liver disease are characterized by autosomal dominant inheritance and numerous hepatic cysts, with or without renal involvement. Mutations in two distinct genes predispose to renal and liver cysts (PKD1 and PKD2), and mutations in two different genes yield isolated liver cysts (PRKCSH and SEC63). Mutations at certain loci of PKD1 may predispose to more severe renal cystic disease or cerebral aneurysms. Risk factors for severe hepatic cystic disease include aging, female sex, pregnancy, use of exogenous female steroid hormones, degree of renal cystic disease, or severity of renal dysfunction (in patients with mutations in PKD1 or PKD2). Although liver failure or complications of advanced liver disease is rare, some patients develop massive hepatic cystic disease and become clinically symptomatic. There is no effective medical therapy. Treatment options include cyst aspiration and sclerosis, open or laparoscopic cyst fenestration, hepatic resection, and liver transplantation.

Management of polycystic liver disease. Publishing Authors By Initials

GT Everson,MR Taylor,GT Everson,MR Taylor,GT Everson,MR Taylor,

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Management of polycystic liver disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current gastroenterology reports

VOLUME: 7

Page Numbers: 19-25

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ISSN: 1522-8037

DAY: 9

MONTH: Feb

YEAR: 2005

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LANGUAGE: eng

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AFFILIATION: Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, 4200 East Ninth Avenue, B-154, Denver, CO 80262, USA. greg.everson@uchsc.edu.

Country: United States

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MEDLINETA: Curr Gastroenterol Rep

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