Management of NSAID-related gastrointestinal mucosal injury.

Management of NSAID-related gastrointestinal mucosal injury. Research Abstract Details 

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Management of NSAID-related gastrointestinal mucosal injury. Abstract Text:

A F Barrison,M M Wolfe,

The three therapeutic goals in patients with NSAID-induced gastroduodenopathy are treatment of dyspeptic symptoms, management of NSAID-related ulcers and their complications, and prophylaxis against recurrent gastrointestinal toxicity. Both H(2)-receptor antagonists and proton pump inhibitors (PPIs) appear to be helpful in relieving the symptoms associated with NSAID use, while treatment of NSAID-induced gastroduodenal ulcers, whether the NSAID is continued or not, is best achieved by the use of PPIs. However, because symptoms do not often predict the presence of gastroduodenal ulcers, the goal of prevention has become paramount in the treatment of patients with an increased likelihood of gastrointestinal toxicity. The best prophylaxis against NSAID-related toxicity is the use of an alternative agent such as salsalate or paracetamol (acetaminophen). However, if an NSAID is to be used, prophylaxis is best accomplished with a PPI or misoprostol, a prostaglandin E1 analogue. The use of misoprostol is limited by its frequent dosing, at least 200 microg three times a day, and its own gastrointestinal side effects. Future therapy will include NSAIDs that maintain their antiinflammatory effects, while possessing superior safety profiles, and include preferential and highly selective COX-2 inhibitors and nitric oxide releasing compounds.

Management of NSAID-related gastrointestinal mucosal injury. Publishing Authors By Initials

AF Barrison,MM Wolfe,

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Management of NSAID-related gastrointestinal mucosal injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Inflammopharmacology

VOLUME: 7

Page Numbers: 277-86

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ISSN: 0925-4692

DAY: 19

MONTH: 07

YEAR: 1999

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LANGUAGE: eng

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AFFILIATION: Section of Gastwenterology, Boston University School of Medicine and Boston Medical Center, 88 East Newton Street, 02118-2393, Boston, Massachusetts MA, USA, Michael.wolfe@bmc.org.

Country: Switzerland

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MEDLINETA: Inflammopharmacology

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