Management and outcomes of hepatic cirrhosis: Findings from the RING study.

Management and outcomes of hepatic cirrhosis: Findings from the RING study. Research Abstract Details 

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Management and outcomes of hepatic cirrhosis: Findings from the RING study. Abstract Text:

M Soncini,P Leo,O Triossi,C Breda,A F Attili,A Mondardini,A Federico,A Cosentini,G Tritto,R Bottelli,F Pompeo,G P Marone,P Bonazzi,M R Magnolia,L Pietrini,M Proietti,V Belfiori,A Tozzi,L A Giglio,R Muratori,A M ,T Grasso,A Spadaccini,M Verta,L Ferraris,S Caruso,R Sega,G Brambilla,

BACKGROUND/AIM: Hepatic cirrhosis is a frequent reason for ordinary hospital admission (OA). The RING study collected hospital discharge files (HDF) from Italian hospital gastroenterology units (IGU). This caselist provides a broad picture of the patients admitted for this pathology. MATERIAL/METHODS: More than 50,000 HDF for OA were collected between 2001 and 2004 from 26 IGU. RESULTS: Eight thousand four hundred and eighty-seven HDF (16%) had a diagnosis of hepatic cirrhosis; Child-Pugh classes were 20.2% A, 34.8% B and 45.0% C. Patients' mean age was 63.7+/-12.1 years and 62.5% were male. A 61.1% of the cirrhosis cases had ascites, 29.9% portal-systemic encephalopathy, 29.2% hepatocellular carcinoma (HCC), 10% bleeding varices, 3.0% hepatorenal syndrome (HRS). Mortality for OA for cirrhosis was 5.7% versus 2.6% for other diagnoses. The proportion varied with the severity of the cirrhosis: 0% for Child A, 1.1% B, 10.5% C. Mortality was significantly associated with: Child-Pugh at admission (odds ratio: OR 9.2), HRS (OR 11.7), bleeding varices (OR 2.2), HCC (OR 1.8). CONCLUSIONS: Hepatic cirrhosis was found in 16% of the OA to IGU and mortality was double the rate for all the other pathologies in the same wards. Child-Pugh is a useful prognostic tool, higher classes implying a greater risk of death. HRS and bleeding varices were the complications with most influence on in-hospital mortality.

Management and outcomes of hepatic cirrhosis: Findings from the RING study. Publishing Authors By Initials

M Soncini,P Leo,O Triossi,C Breda,AF Attili,A Mondardini,A Federico,A Cosentini,G Tritto,R Bottelli,F Pompeo,GP Marone,P Bonazzi,MR Magnolia,L Pietrini,M Proietti,V Belfiori,A Tozzi,LA Giglio,R Muratori,AM ,T Grasso,A Spadaccini,M Verta,L Ferraris,S Caruso,R Sega,G Brambilla,

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Management and outcomes of hepatic cirrhosis: Findings from the RING study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 36

Page Numbers: 176-81

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 11

MONTH: 09

YEAR: 2006

Management and outcomes of hepatic cirrhosis: Findings from the RING study. Information

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LANGUAGE: eng

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AFFILIATION: Gastroenterology, S. Carlo Borromeo Hospital, Via Pio II 3, 20153 Milano, Italy.

Country: Netherlands

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MEDLINETA: Hepatol Res

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