Mamu-B*08-positive macaques control simian immunodeficiency virus replication.

Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Research Abstract Details 

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Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Abstract Text:

John T Loffredo,Jess Maxwell,Ying Qi,Chrystal E Glidden,Gretta J Borchardt,Taeko Soma,Alex T Bean,Dominic R Beal,Nancy A Wilson,William M Rehrauer,Jeffrey D Lifson,Mary Carrington,David I Watkins,

Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV(mac)239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.

Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Publishing Authors By Initials

JT Loffredo,J Maxwell,Y Qi,CE Glidden,GJ Borchardt,T Soma,AT Bean,DR Beal,NA Wilson,WM Rehrauer,JD Lifson,M Carrington,DI Watkins,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 8827-32

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 30

MONTH: 05

YEAR: 2007

Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: immunology

Chemical & Substance for Abstract: Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Information

Substance Name: Histocompatibility Antigens Class I

Registry Number: 0

Grant and Affiliation Information for Mamu-B*08-positive macaques control simian immunodeficiency virus replication.

AFFILIATION: Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR 15459-01

ACRONYM: RR

MEDLINETA: J Virol

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