Mammary gland development in early pubertal female macaques.

Mammary gland development in early pubertal female macaques. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mammary gland development in early pubertal female macaques. Abstract Text:

Charles E Wood,Joy M Hester,J Mark Cline,Charles E Wood,Joy M Hester,J Mark Cline,Charles E Wood,Joy M Hester,J Mark Cline,

Ductal morphogenesis of the mammary gland occurs largely in the early pubertal period under the influence of ovarian sex hormones. In this study we characterized developing ductal structures in breast tissue of 14 female prepubertal or early pubertal rhesus monkeys (average age, 2.6 +/- 0.1 years). Serum estradiol concentrations ranged from < 5.0 to 61.2 pg/ml, while progesterone concentrations were low in all animals (< 0.6 ng/ml). No corpora lutea were seen on ovarian histology. The most immature mammary glands contained multilayered ducts frequently ending in distinctive terminal end bud structures. Transitional ducts had variably stratified columnar epithelium, often with prominent rounded myoepithelial cells and loose periductal stroma. Mature ducts had simple cuboidal luminal epithelium, flattened myoepithelium, and associated lobular development, typical of the premenopausal breast. Expression of estrogen receptor alpha was significantly higher in immature ducts compared to mature ducts, while progesterone receptor expression, epithelial proliferation, and cytokeratin expression did not show a relationship to the maturity of the ducts. These findings identify dynamic morphologic changes occurring in the primate breast during early puberty and suggest that estradiol (rather than progesterone) is the predominant hormonal stimulus for early ductal and lobular development.

Mammary gland development in early pubertal female macaques. Publishing Authors By Initials

CE Wood,JM Hester,JM Cline,CE Wood,JM Hester,JM Cline,CE Wood,JM Hester,JM Cline,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Mammary gland development in early pubertal female macaques. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Toxicologic pathology

VOLUME: 35

Page Numbers: 793-803

Journal Abbreviation:

ISSN: 0192-6233

DAY: 18

MONTH: 10

YEAR: 2007

Mammary gland development in early pubertal female macaques. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905907

Mammary gland development in early pubertal female macaques. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Mammary gland development in early pubertal female macaques. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mammary gland development in early pubertal female macaques.

AFFILIATION: Department of Pathology/Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Toxicol Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mammary gland development in early pubertal female macaques Related Publications

• 3DFT MR angiography of carotid and basilar arteries.
• A correlated study of tuberculin, histoplasmin and coccidioidin sensitivities with pulmonary calcifications in the Rocky Mountain area.
• A day in the life of an orthodontic assistant.
• Adrenal steroids in leukemia and lymphoma.
• Biotechnology and the new right: a progressive red herring?
• Cesium-137 movement in a root-soil profile. BNWL-480.
• Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.
• Decreases in plasma volume during electrically induced convulsions in man.
• Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis).
• Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys.
• Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model.
• Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys.
• Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.
• Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeys.
• Gold foil; the class five restoration.
• Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys.
• Insertion of drug resistance genes in animals.
• Mammary gland development in early pubertal female macaques.
• Radioiodine environment release studies. BNWL-280.
• Reaching kids with reactive attachment disorder.
• Refining the roles of GABAergic signaling during neural circuit formation.
• Roles of NR2A and NR2B in the Development of Dendritic Arbor Morphology In Vivo.
• Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys.
• Technology and outpatient review: a preliminary evaluation.
• The management of retained placenta; a plea for manual removal.
• The menace of socialized medicine.
• The thylakoid proton gradient promotes an advanced stage of signal peptide binding deep within the Tat pathway receptor complex.
• [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)]
• [Incidence and clinical features of arrhythmias after surgical treatment of congenital heart disease]
• beta-Melanocyte-Stimulating Hormone Potently Reduces Appetite Via the Hypothalamus in Chicks.