Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor.

Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor. Research Abstract Details 

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Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor. Abstract Text:

Specimens from 17 invasive primary breast adenocarcinomas that showed distinct areas of different histologic appearance were examined with respects to nuclear DNA content of the tumor cells. DNA in individual tumor cells was measured in sections from the original paraffin-embedded specimens. DNA distribution patterns obtained from the histologically different areas in the same tumor were compared. In 15 cases these patterns were very similar, whereas in two cases the patterns were found to be different. The results suggest that, in spite of histological variations, breast carcinoma often show similar nuclear DNA content throughout the entire tumor. Since nuclear DNA content in breast tumors has been shown to be correlated to prognosis, our observations suggest that the differences in structural pattern occasionally seen in mammary adenocarcinoma do not necessarily reflect a dedifferentiation towards more malignant tumor populations.

Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor. Publishing Authors By Initials

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica, microbiologica, et immunologica

VOLUME: 94

Page Numbers: 21-8

Journal Abbreviation:

ISSN: 0108-0164

DAY: 26

MONTH: Jan

YEAR: 1986

Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor. Information

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LANGUAGE: eng

NlmUniqueID: 8206622

Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: analysis

Chemical & Substance for Abstract: Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor. Information

Substance Name: DNA, Neoplasm

Registry Number: 0

Grant and Affiliation Information for Mammary carcinoma: DNA analysis in areas showing different histological features in the same tumor.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Immunol

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