Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases.

Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Research Abstract Details 

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Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Abstract Text:

Emily Joo,Mark C Surka,William S Trimble,Emily Joo,Mark C Surka,William S Trimble,

Mammalian septin SEPT2 belongs to a conserved family of filamentous GTPases that are associated with actin stress fibers in interphase cells and the contractile ring in dividing cells. Although SEPT2 is essential for cytokinesis, its role in this process remains undefined. Here, we report that SEPT2 directly binds nonmuscle myosin II (myosin II), and this association is important for fully activating myosin II in interphase and dividing cells. Inhibition of the SEPT2-myosin II interaction in interphase cells results in loss of stress fibers, while in dividing cells this causes instability of the ingressed cleavage furrow and dissociation of the myosin II from the Rho-activated myosin kinases ROCK and citron kinase. We propose that SEPT2-containing filaments provide a molecular platform for myosin II and its kinases to ensure the full activation of myosin II that is necessary for the final stages of cytokinesis.

Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Publishing Authors By Initials

E Joo,MC Surka,WS Trimble,E Joo,MC Surka,WS Trimble,

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Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental cell

VOLUME: 13

Page Numbers: 677-90

Journal Abbreviation: Dev. Cell

ISSN: 1534-5807

DAY: 5

MONTH: Nov

YEAR: 2007

Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Information

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LANGUAGE: eng

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AFFILIATION: Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

Country: United States

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MEDLINETA: Dev Cell

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