Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals.

Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Research Abstract Details 

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Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Abstract Text:

Jonathan B Pollett,Karin A Corsi,Kurt R Weiss,Gregory M Cooper,Denise A Barry,Burhan Gharaibeh,Johnny Huard,

Recent studies have shown that germ-line determination occurs early in development and that extracellular signaling can alter this fate. This denial of a cell's fate by counteracting its intrinsic signaling pathways through extrinsic stimulation is believed to be associated with oncogenesis. Using specific populations of multipotent skeletal muscle-derived stem cells (MDSCs), we have been able to generate tumors by subjecting cells with specific lineage predilections to concomitant differentiation signals. More specifically, when a stem cell that had a predilection toward osteogenesis was implanted into a skeletal muscle, tumors formed in 25% of implanted mice. When cells predilected to undergo myogenesis were pretreated with bone morphogenetic protein 4 (BMP4) for 4 days prior to implantation, they formed tumors in 25% of mice. These same myogenic predilected cells, when transduced to express BMP4 and implanted into either a long-bone or cranial defect, formed bone, but they formed tumors in 100% of mice when implanted into the skeletal muscle. The tumors generated in this latter study were serially transplantable as long as they retained BMP4 expression. Furthermore, when we impeded the ability of the cells to undergo myogenic differentiation using small interfering RNA to the myogenic regulator MyoD1, we stopped transformation. Based on our findings, we postulate that specific MDSC populations can undergo concomitant signal-induced transformation and that the initial stages of transformation may be due to changes in the balance between the inherent nature of the cell and extrinsic signaling pathways. This theory represents a potential link between somatic stem cells and cancer and suggests an involvement of the niche/environment in transformation.

Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Publishing Authors By Initials

JB Pollett,KA Corsi,KR Weiss,GM Cooper,DA Barry,B Gharaibeh,J Huard,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Stem cells (Dayton, Ohio)

VOLUME: 25

Page Numbers: 2302-11

Journal Abbreviation: Stem Cells

ISSN: 1549-4918

DAY: 14

MONTH: 06

YEAR: 2007

Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9304532

Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Information

Substance Name: noggin protein

Registry Number: 148294-77-3

Grant and Affiliation Information for Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals.

AFFILIATION: Stem Cell Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: R01-DE13420-01

ACRONYM: DE

MEDLINETA: Stem Cells

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