MALDI-MS-based imaging of small molecules and proteins in tissues.

MALDI-MS-based imaging of small molecules and proteins in tissues. Research Abstract Details 

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MALDI-MS-based imaging of small molecules and proteins in tissues. Abstract Text:

Michelle L Reyzer,Richard M Caprioli,

The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds present in tissues to be detected with molecular specificity while maintaining their spatial orientation. This unique combination, coupled with excellent sensitivity and rapid analysis time, presents many potential advantages to a wide range of applications in diverse biological fields. Recent advances have shown how the technique can be applied to cancer research, neuroscience and pharmaceutical development. Examples include the use of unique protein profiles to classify human tumor tissues and predict patient outcomes, the discovery of protein changes in mouse cerebellum as a function of development, and the two-dimensional visualization of the distribution of a drug and first-pass metabolites in rat whole-body sections.

MALDI-MS-based imaging of small molecules and proteins in tissues. Publishing Authors By Initials

ML Reyzer,RM Caprioli,

For similar complex mixtures: tissue extracts research abstracts see: complex mixtures: tissue extracts research

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MALDI-MS-based imaging of small molecules and proteins in tissues. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in chemical biology

VOLUME: 11

Page Numbers: 29-35

Journal Abbreviation:

ISSN: 1367-5931

DAY: 20

MONTH: 12

YEAR: 2006

MALDI-MS-based imaging of small molecules and proteins in tissues. Information

Number of References: 29

LANGUAGE: eng

NlmUniqueID: 9811312

MALDI-MS-based imaging of small molecules and proteins in tissues. Keywords Mesh Terms:

KEYWORDS: Tissue Extracts

MESH TERMS: metabolism

Chemical & Substance for Abstract: MALDI-MS-based imaging of small molecules and proteins in tissues. Information

Substance Name: Tissue Extracts

Registry Number: 0

Grant and Affiliation Information for MALDI-MS-based imaging of small molecules and proteins in tissues.

AFFILIATION: Mass Spectrometry Research Center, Vanderbilt University, Room 9160, Medical Research Building III, Nashville, TN 37232-8575 USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM58008

ACRONYM: GM

MEDLINETA: Curr Opin Chem Biol

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