Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells.

Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells. Research Abstract Details 

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Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells. Abstract Text:

Tomoyo Taniguchi,Saoko Tachikawa,Yasuhiro Kanda,Toshihiko Kawamura,Chikako Tomiyama-Miyaji,Changchun Li,Hisami Watanabe,Hiroho Sekikawa,Toru Abo,Tomoyo Taniguchi,Saoko Tachikawa,Yasuhiro Kanda,Toshihiko Kawamura,Chikako Tomiyama-Miyaji,Changchun Li,Hisami Watanabe,Hiroho Sekikawa,Toru Abo,

It is still controversial whether malaria protection is mediated by conventional immunity associated with T and B cells or by innate immunity associated with extrathymic T cells and autoantibody-producing B cells. Given this situation, it is important to examine the mechanism of malaria protection in beta(2)-microglobulin-deficient (beta(2)m(-/-)) mice. These mice lack major histocompatibility complex class I and CD1d antigens, which results in the absence of CD8(+) T cells and natural killer T (NKT) cells. When C57BL/6 and beta(2)m(-/-) mice were injected with parasitized (Plasmodium yoelii 17XNL) erythrocytes, both survived from the infection and showed a similar level of parasitaemia. The major expanding T cells were NK1.1(-) alphabeta T-cell receptor(int) cells in both mice. The difference was a compensatory expansion of NK and gammadelta T cells in beta(2)m(-/-) mice, and an elimination experiment showed that these lymphocytes were critical for protection in these mice. These results suggest that malaria protection might be events of the innate immunity associated with multiple subsets with autoreactivity. CD8(+) T and NKT cells may be partially related to this protection.

Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells. Publishing Authors By Initials

T Taniguchi,S Tachikawa,Y Kanda,T Kawamura,C Tomiyama-Miyaji,C Li,H Watanabe,H Sekikawa,T Abo,T Taniguchi,S Tachikawa,Y Kanda,T Kawamura,C Tomiyama-Miyaji,C Li,H Watanabe,H Sekikawa,T Abo,

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Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunology

VOLUME: 122

Page Numbers: 514-21

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ISSN: 1365-2567

DAY: 3

MONTH: 10

YEAR: 2007

Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells. Information

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LANGUAGE: eng

NlmUniqueID: 374672

Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells. Keywords Mesh Terms:

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Grant and Affiliation Information for Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells.

AFFILIATION: Department of Immunology, Niigata University School of Medicine, Niigata, Japan.

Country: England

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MEDLINETA: Immunology

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