Making and breaking contacts: the cellular biology of cadherin regulation.

Making and breaking contacts: the cellular biology of cadherin regulation. Research Abstract Details 

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Making and breaking contacts: the cellular biology of cadherin regulation. Abstract Text:

Alpha S Yap,Matthew S Crampton,Jeff Hardin,Alpha S Yap,Matthew S Crampton,Jeff Hardin,Alpha S Yap,Matthew S Crampton,Jeff Hardin,

Cadherin-mediated cell-cell interactions are dynamic processes, and cadherin function is tightly regulated in response to cellular context and signaling. Ultimately, cadherin regulation is likely to reflect the interplay between a range of fundamental cellular processes, including surface organization of receptors, cytoskeletal organization and cell trafficking, that are coordinated by signaling events. In this review we focus on recent advances in understanding how interplay with membrane trafficking and other cell-cell junctions can control cadherin function. The endocytosis of cadherins, and their post-internalization fate, influences surface expression and metabolic stability of these adhesion receptors. Similarly, at the surface, components of tight junctions provide a mode of cross-talk that regulates assembly of adherens junctions.

Making and breaking contacts: the cellular biology of cadherin regulation. Publishing Authors By Initials

AS Yap,MS Crampton,J Hardin,AS Yap,MS Crampton,J Hardin,AS Yap,MS Crampton,J Hardin,

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Making and breaking contacts: the cellular biology of cadherin regulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in cell biology

VOLUME: 19

Page Numbers: 508-14

Journal Abbreviation: Curr. Opin. Cell Biol.

ISSN: 0955-0674

DAY: 5

MONTH: Oct

YEAR: 2007

Making and breaking contacts: the cellular biology of cadherin regulation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Making and breaking contacts: the cellular biology of cadherin regulation.

AFFILIATION: Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia.

Country: United States

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MEDLINETA: Curr Opin Cell Biol

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