Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis.

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Research Abstract Details 

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Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Abstract Text:

Emma Guttman-Yassky,Michelle A Lowes,Judilyn Fuentes-Duculan,Julia Whynot,Inna Novitskaya,Irma Cardinale,Asifa Haider,Artemis Khatcherian,John A Carucci,Reuven Bergman,James G Krueger,

BACKGROUND: Atopic dermatitis (AD) and psoriasis represent contrasting poles of the T(H)1 versus T(H)2 paradigm. Both diseases have been associated with increased numbers of dendritic cells (DCs) in the skin, but the similarities and differences in DC populations need to be established. OBJECTIVE: We aimed to characterize the specific DC subsets, as well as chemokine and cytokine environment in chronic AD compared with psoriasis. METHODS: Skin biopsies were obtained from patients with acute exacerbation of chronic AD (n = 18), psoriasis (n = 15), and healthy volunteers (n = 15) for microarray analysis, RT-PCR, immunohistochemistry, and double-label immunofluorescence. RESULTS: Myeloid DCs upregulate CCL17 and CCL18 in AD, as opposed to TNF-alpha and inducible nitric oxide synthase (iNOS) in psoriasis. In our study, we identified cells phenotypically identical to the inflammatory dendritic epidermal cells in the dermis in both diseases, although to a lesser extent in psoriasis. We found substantially higher numbers of dermal CCL22 producing plasmacytoid DCs in AD. The thymic stromal lymphopoietin receptor showed significantly higher expression in AD, whereas the thymic stromal lymphopoietin ligand was upregulated more in psoriasis. CONCLUSION: There are major differences in myeloid and plasmacytoid subsets of cutaneous DCs and the chemokine/cytokine environment between AD and psoriasis. Distinct subsets within the CD11c(+) population may influence polarization through the production of regulatory mediators, including iNOS, TNF, CCL17, and CCL18. Plasmacytoid DCs may also influence T(H)2 polarization, having a more important role in AD than previously appreciated. CLINICAL IMPLICATIONS: Dermal inflammatory dendritic cells in AD and TNF and iNOS-producing DCs in psoriasis, and/or their regulatory products, may be potential targets for future therapeutic interventions.

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Publishing Authors By Initials

E Guttman-Yassky,MA Lowes,J Fuentes-Duculan,J Whynot,I Novitskaya,I Cardinale,A Haider,A Khatcherian,JA Carucci,R Bergman,JG Krueger,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of allergy and clinical immunology

VOLUME: 119

Page Numbers: 1210-7

Journal Abbreviation:

ISSN: 0091-6749

DAY: 3

MONTH: May

YEAR: 2007

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1275002

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

Chemical & Substance for Abstract: Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Information

Substance Name: Cytokines

Registry Number: 0

Grant and Affiliation Information for Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis.

AFFILIATION: Laboratory for Investigative Dermatology, Rockefeller University, New York, NY 10021, USA.

Country: United States

AGENCY: United States NCRR

GRANT: UL1RR024143

ACRONYM: RR

MEDLINETA: J Allergy Clin Immunol

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