Maintenance of superior learning and memory function in NR2B transgenic mice during ageing.

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Research Abstract Details 

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Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Abstract Text:

Xiaohua Cao,Zhenzhong Cui,Ruiben Feng,Ya-Ping Tang,Zhenxia Qin,Bing Mei,Joe Z Tsien,

Brain ageing represents a general and evolutionarily conserved phenomenon and is marked by gradual declines in cognitive functions such as learning and memory. As a synaptic coincidence detector, the N-methyl-d-aspartate (NMDA) receptor is known to be essential for the induction of synaptic plasticity and memory formation. Here, we test the hypothesis that up-regulation of NR2B expression is beneficial for learning and memory in the aged animals. Our in vitro recordings show that the aged transgenic mice with the forebrain-specific overexpression of the NR2B subunit indeed exhibit more robust hippocampal long-term potentiation (LTP) induced by either high-frequency stimulation or theta-stimulation protocol. Furthermore, those aged NR2B transgenic mice consistently outperform their wild-type littermates in five different learning and memory tests, namely, novel object recognition, contextual and cued fear conditioning, spatial reference memory, and spatial working memory T-maze task. Thus, we conclude that increased expression of NR2B in the forebrain improves learning and memory function in the aged brain.

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Publishing Authors By Initials

X Cao,Z Cui,R Feng,YP Tang,Z Qin,B Mei,JZ Tsien,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 25

Page Numbers: 1815-22

Journal Abbreviation:

ISSN: 0953-816X

DAY: 3

MONTH: Mar

YEAR: 2007

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: physiology

Chemical & Substance for Abstract: Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Information

Substance Name: Receptors, N-Methyl-D-Aspartate

Registry Number: 0

Grant and Affiliation Information for Maintenance of superior learning and memory function in NR2B transgenic mice during ageing.

AFFILIATION: Shanghai Institute of Brain Functional Genomics, The Key laboratories of MOE and SSTC, East China Normal University, Shanghai, China. xhcao@brain.ecnu.edu.cn

Country: France

AGENCY: United States NIMH

GRANT: MH62632

ACRONYM: MH

MEDLINETA: Eur J Neurosci

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