Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS.

Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS. Research Abstract Details 

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Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS. Abstract Text:

Pavel Bostik,Susan T Stephenson,Rebecca M Lynch,Adriana Cardona,Aftab A Ansari,Pavel Bostik,Susan T Stephenson,Rebecca M Lynch,Adriana Cardona,Aftab A Ansari,Pavel Bostik,Susan T Stephenson,Rebecca M Lynch,Adriana Cardona,Aftab A Ansari,

A PCR-based assay was established to screen for potential changes in the heterogeneity of Vbeta TCR expressing CD4(+) T cells from rhesus macaques (RM) and sooty mangabeys (SM) prior to and following SIV infection. The rationale for these studies was to determine whether the progressive CD4(+) T cell loss in SIV-infected disease susceptible RM and the moderate CD4(+) T cell loss in disease resistant SM leads to the depletion of select Vbeta TCR families of CD4(+) T cells. Results show that whereas SIV infection leads to the loss of Vbeta TCR heterogeneity in disease susceptible RM, the CD4(+) T cells from SM retain their degree of Vbeta TCR heterogeneity, suggesting that the mechanism(s) of SIV induced CD4(+) T cell loss maybe distinct in these 2 species and contribute to the differences in the clinical outcome.

Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS. Publishing Authors By Initials

P Bostik,ST Stephenson,RM Lynch,A Cardona,AA Ansari,P Bostik,ST Stephenson,RM Lynch,A Cardona,AA Ansari,P Bostik,ST Stephenson,RM Lynch,A Cardona,AA Ansari,

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Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virology

VOLUME: 369

Page Numbers: 324-8

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 21

MONTH: 09

YEAR: 2007

Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS. Information

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LANGUAGE: eng

NlmUniqueID: 110674

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Grant and Affiliation Information for Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS.

AFFILIATION: Department of Pathology and Laboratory Medicine, Emory University, WMB rm#2337A, 101 Woodruff Circle, Atlanta, GA 30322, USA.

Country: United States

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MEDLINETA: Virology

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