Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis.

Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis. Research Abstract Details 

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Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis. Abstract Text:

Uner Kayabas,Alpay Alkan,Ahmet Kemal Firat,Hakki Muammer Karakas,Yasar Bayindir,Funda Yetkin,

We aimed to evaluate whether the subtle metabolic cerebral changes are present in normal-appearing white matter on conventional MRI, in patients with acute brucellosis, by using MR spectroscopy (MRS). Sixteen patients with acute brucellosis and 13 healthy control subjects were investigated with conventional MRI and single-voxel MRS. Voxels were placed in normal-appearing parietal white matter (NAPWM). N-Acetyl aspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were calculated. There was no significant difference between the study subjects and the control group in NAA/Cr ratios obtained from NAPWM. However, the Cho/Cr ratios were significantly higher in patients with acute brucellosis compared to controls (p=0.01). MRS revealed metabolic changes in normal-appearing white matter of patients with brucellosis. Brucellosis may cause subtle cerebral alterations, which may only be discernible with MRS. Increased Cho/Cr ratio possibly represents an initial phase of inflammation and/or demyelination process of brucellosis.

Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis. Publishing Authors By Initials

U Kayabas,A Alkan,AK Firat,HM Karakas,Y Bayindir,F Yetkin,

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Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of radiology

VOLUME: 65

Page Numbers: 417-20

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ISSN: 0720-048X

DAY: 24

MONTH: 10

YEAR: 2007

Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis.

AFFILIATION: Department of Infectious Disease and Clinical Microbiology, Inonu University, Medical Faculty, TR-44280 Malatya, Turkiye.

Country: Ireland

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MEDLINETA: Eur J Radiol

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