Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe of patients with sturge-weber syndrome.

Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe of patients with sturge-weber syndrome. Research Abstract Details 

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Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe of patients with sturge-weber syndrome. Abstract Text:

BACKGROUND In Sturge-Weber syndrome (SWS), structural MRI abnormalities are most common in the posterior brain regions. Frontal lobe involvement increases the risk of motor impairment. The goal of this study was to determine whether Magnetic Resonance Spectroscopic Imaging (MRSI) can improve detection of frontal lobe involvement in children with SWS. METHODS Sixteen children (age: .9-10.4 years) with unilateral SWS underwent MRI with MRSI prospectively. N-acetyl-aspartate (NAA) and choline asymmetries in the posterior and frontal regions were measured. RESULTS Eight children presented normal-appearing frontal lobes on conventional MRI, but 7 of them showed abnormal NAA and/or choline content in the frontal lobe of the affected hemisphere. Lower frontal lobe gray matter NAA was associated with earlier onset of seizures (r= .76; P= .04) and impaired motor function (r=-.89, P < .001). Frontal NAA asymmetry was an independent predictor of motor function in a regression analysis (P= .01) CONCLUSION MRSI is more sensitive than conventional structural MRI for detection of frontal lobe involvement in SWS. Decreased frontal lobe NAA is an excellent predictor of motor functions. Thus, MRSI can provide complementary information for the assessment of normal-appearing brain regions, and may assist prognosis evaluation in children with SWS.

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Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe of patients with sturge-weber syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neuroimaging : official journal of the

VOLUME: 18

Page Numbers: 306-13

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ISSN: 1552-6569

DAY: 23

MONTH: Jul

YEAR: 2008

Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe of patients with sturge-weber syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 9102705

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Grant and Affiliation Information for Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe of patients with sturge-weber syndrome.

AFFILIATION: Department of Pediatrics, Radiology, Wayne State University, Detroit, Michigan; Departments of Neurology and Radiology, Wayne State University, Detroit, Michigan; Department of Radiology, Wayne State University, Detroit, Michigan.

Country: United States

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MEDLINETA: J Neuroimaging

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