Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy.

Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. Research Abstract Details 

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Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. Abstract Text:

Florian Eichler,Asif Mahmood,Daniel Loes,Lena Bezman,Doris Lin,Hugo W Moser,Gerald V Raymond,

BACKGROUND: An inherited disorder, X-linked adrenoleukodystrophy (X-ALD) is known to cause progressive inflammatory demyelination. OBJECTIVE: To analyze the adult pattern of disease progression in X-ALD. DESIGN, SETTING, AND PATIENTS: We retrospectively assessed magnetic resonance (MR) images obtained in adult patients who had developed cerebral disease between January 1, 1985, and December 31, 2005. We identified 103 adult patients with X-ALD with lesions on their MR images. Of these, 56 had serial MR examinations at least 1 year apart and were included in this study. Main Outcome Measure Progression of X-ALD lesions on MR images. RESULTS: On initial presentation, 17 patients with X-ALD had corticospinal tract lesions without splenium or genu involvement, 24 had symmetric corticospinal tract lesions with additional involvement of the splenium or genu, and 15 did not have corticospinal tract involvement but had other white matter lesions. In 18 of 21 patients with progressive lesions, corticospinal tract involvement preceded or occurred concurrently with progressive inflammatory demyelination. CONCLUSIONS: Brain MR imaging abnormalities in adults with X-ALD progress slower than those reported in childhood. The involvement of the corticospinal tracts is prominent and may at times represent a variant course of progressive inflammatory demyelination.

Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. Publishing Authors By Initials

F Eichler,A Mahmood,D Loes,L Bezman,D Lin,HW Moser,GV Raymond,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research

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Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of neurology

VOLUME: 64

Page Numbers: 659-64

Journal Abbreviation: Arch. Neurol.

ISSN: 0003-9942

DAY: 3

MONTH: May

YEAR: 2007

Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. Information

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LANGUAGE: eng

NlmUniqueID: 372436

Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. Keywords Mesh Terms:

KEYWORDS: Retrospective Studies

MESH TERMS: pathology

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Grant and Affiliation Information for Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy.

AFFILIATION: Department of Neurology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M0RR11

ACRONYM: RR

MEDLINETA: Arch Neurol

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