Magnetic resonance imaging and spectroscopy of the rat hippocampus 1 month after exposure to (56)fe-particle radiation.

Magnetic resonance imaging and spectroscopy of the rat hippocampus 1 month after exposure to (56)fe-particle radiation. Research Abstract Details 

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Magnetic resonance imaging and spectroscopy of the rat hippocampus 1 month after exposure to (56)fe-particle radiation. Abstract Text:

A Obenaus,L Huang,A Smith,C J Favre,G Nelson,E Kendall,A Obenaus,L Huang,A Smith,C J Favre,G Nelson,E Kendall,

Obenaus, A., Huang, L., Smith, A., Favre, C. J., Nelson, G. and Kendall, E. Magnetic Resonance Imaging and Spectroscopy of the Rat Hippocampus 1 Month after Exposure to (56)Fe-Particle Radiation. Radiat. Res. 169, 149-161 (2008).The response of the central nervous system to space radiation is largely unknown. The hippocampus, which is known for its critical role in learning and memory, was evaluated for its response to heavy-ion radiation. At 1 month, animals exposed to brain-only (56)Fe-particle irradiation (0-4 Gy) were examined using contrast-enhanced T1 imaging (CET1), T2-weighted imaging (T2WI), diffusion weighted imaging (DWI), and (1)H-magnetic resonance spectroscopy (MRS). Correlative histology was performed after imaging. The T2WI, DWI and CET1 images revealed no overt anatomical changes after irradiation. Quantitative analysis demonstrated a significant increase in T2 at 2 Gy compared to 0 Gy. The apparent diffusion coefficient (ADC) revealed an inverse dose-dependent quantitative change in water mobility. Compared to 0 Gy, the ADC increased 122% at 1 Gy and declined to 44% above control levels at 4 Gy. MRS showed a significant increase in the N-acetylaspartate/choline ratio at 4 Gy and a lactate peak. Histology demonstrated no overt pathological changes in neuronal and astrocyte populations. However, a significant inverse dose-dependent morphological change in the microglial population was detected in irradiated animals. Our results suggest that early tissue matrix modifications induced by (56)Fe-particle radiation can be detected by MRI in the absence of evident histopathology. These changes may indicate fundamental changes in the structure and function of the hippocampus.

Magnetic resonance imaging and spectroscopy of the rat hippocampus 1 month after exposure to (56)fe-particle radiation. Publishing Authors By Initials

A Obenaus,L Huang,A Smith,CJ Favre,G Nelson,E Kendall,A Obenaus,L Huang,A Smith,CJ Favre,G Nelson,E Kendall,

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Magnetic resonance imaging and spectroscopy of the rat hippocampus 1 month after exposure to (56)fe-particle radiation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Radiation research

VOLUME: 169

Page Numbers: 149-61

Journal Abbreviation: Radiat. Res.

ISSN: 0033-7587

DAY: 28

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

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