Magnetic resonance-guided high-intensity ultrasound ablation of the prostate.

Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Abstract Text:

Kim Butts Pauly,Chris J Diederich,Viola Rieke,Donna Bouley,Jing Chen,Will H Nau,Anthony B Ross,Adam M Kinsey,Graham Sommer,

OBJECTIVES: This paper describes our work in developing techniques and devices for magnetic resonance (MR)-guided high-intensity ultrasound ablation of the prostate and includes review of relevant literature. METHODS: Catheter-based high-intensity ultrasound applicators, in interstitial and transurethral configurations, were developed to be used under MR guidance. Magnetic resonance thermometry and the relevant characteristics and artifacts were evaluated during in vivo thermal ablation of the prostate in 10 animals. Contrast-enhanced MR imaging (MRI) and diffusion-weighted MRI were used to assess tissue damage and compared with histology. RESULTS: During evaluation of these applicators, MR thermometry was used to monitor the temperature distributions in the prostate in real time. Magnetic resonance-derived maximum temperature thresholds of 52 degrees C and thermal dose thresholds of 240 minutes were used to control the extent of treatment and qualitatively correlated well with posttreatment imaging studies and histology. The directional transurethral devices are selective in their ability to target well-defined regions of the prostate gland and can be rotated in discrete steps to conform treatment to prescribed boundaries. The curvilinear applicator is the most precise of these directional techniques. Multisectored transurethral applicators, with dynamic angular control of heating and no rotation requirements, offer a fast and less complex means of treatment with less selective contouring. CONCLUSIONS: The catheter-based ultrasound devices can produce spatially selective regions of thermal destruction in prostate. The MR thermal imaging and thermal dose maps, obtained in multiple slices through the target volume, are useful for controlling therapy delivery (rotation, power levels, duration). Contrast-enhanced T1-weighted MRI and diffusion-weighted imaging are useful tools for assessing treatment.

Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Publishing Authors By Initials

KB Pauly,CJ Diederich,V Rieke,D Bouley,J Chen,WH Nau,AB Ross,AM Kinsey,G Sommer,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Journal Published:

PUBLICATION TYPE: Review

Journal: Topics in magnetic resonance imaging : TMRI

VOLUME: 17

Page Numbers: 195-207

Journal Abbreviation:

ISSN: 0899-3459

DAY: 3

MONTH: Jun

YEAR: 2006

Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8913523

Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Keywords Mesh Terms:

KEYWORDS: Ultrasound, High-Intensity Focused, Tran

MESH TERMS: methods

Chemical & Substance for Abstract: Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Magnetic resonance-guided high-intensity ultrasound ablation of the prostate.

AFFILIATION: Department of Radiology, Stanford University, Stanford, CA 94305-5488, USA. kimbutts@stanford.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA111981

ACRONYM: CA

MEDLINETA: Top Magn Reson Imaging

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Magnetic resonance-guided high-intensity ultrasound ablation of the prostate Related Publications

• A large-scale validation of dosage analysis by robust dosage-polymerase chain reaction.
• A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin.
• A novel image formation method for ultrasonic strain imaging.
• Analysis of urinary calculi using an infrared microspectroscopic surface reflectance imaging technique.
• Anticytokine therapy in neuropathic pain management.
• Antiinfectives and low-level light: a new chapter in photomedicine.
• Autonomic neurogenesis and apoptosis are alternative fates of progenitor cell communities induced by TGFbeta.
• Candidate gene analyses by scanning or brute force fluorescent sequencing: a comparison of DOVAM-S with gel-based and capillary-based sequencing.
• Classification and management of tracheoesophageal and tracheopharyngeal fistulas after laryngectomy.
• Detection of ultrarare somatic mutation in the human TP53 gene by bidirectional pyrophosphorolysis-activated polymerization allele-specific amplification.
• Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies.
• Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice.
• Evidence for mutation showers.
• Evolution of development in nematodes related to C. elegans.
• FDG-PET and FDG-PET/CT in breast cancer.
• Facial attractiveness modulates early and late event-related brain potentials.
• Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs.
• High-resolution myocardial perfusion imaging at 3 T: comparison to 1.5 T in healthy volunteers.
• In vitro comparison of human fibroblasts from intact and ruptured ACL for use in tissue engineering.
• Magnetic resonance-guided high-intensity ultrasound ablation of the prostate.
• Mean-field treatment of polymer chains trapped between surfaces and penetrable interfaces.
• Molecular Structure and Theoretical Studies of (PPh(4))(2)[Bi(10)Cu(10)(SPh)(24)].
• Pristionchus pacificus.
• Random copolymers at a selective interface: Saturation effects.
• The ClpPX protease is required for radioresistance and regulates cell division after gamma-irradiation in Deinococcus radiodurans.
• The Nematode Pristionchus pacificus (Nematoda: Diplogastridae) Is Associated with the Oriental Beetle Exomala orientalis (Coleoptera: Scarabaeidae) in Japan.
• Toward a fluorescent single-strand conformation polymorphism technique that detects all mutations: F-DOVAM-S.
• Treatment of lymphangioma circumscriptum with the intense pulsed light system.
• [Physical training in the treatment of depressive disorders]
• [Stem cells of the enteric nervous system: causal therapy for Hirschsprung's disease?]