Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies.

Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Research Abstract Details 

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Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Abstract Text:

Jacob M Hooker,Ankona Datta,Mauro Botta,Kenneth N Raymond,Matthew B Francis,

Two high-relaxivity nanoscale magnetic resonance contrast agents have been built using bacteriophage MS2 as a biomolecular scaffold. Protein capsid shells were functionalized on either the exterior or interior surface to display multiple copies of an aldehyde functional group. Subsequently, approximately 90 heteropodal bis(hydroxypyridonate)terephthalamide ligands were attached to these sites through oxime condensation reactions. Upon complexation with Gd3+, contrast agents with ionic relaxivities of up to 41.6 mM-1 s-1 (30 MHz, 25 degrees C) and total molecular relaxivities of up to 3900 mM-1 s-1 (30 MHz, 25 degrees C) were produced. Capsids sequestering the Gd-chelates on the interior surface (attached through tyrosine residues) not only provided higher relaxivities than their exterior functionalized counterparts (which relied on lysine modification) but also exhibited improved water solubility and capsid stability. The attachment functional cargo to the interior surface is envisioned to minimize its influences on biodistribution, yielding significant advantages for tissue targeting by additional groups attached to the capsid exterior.

Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Publishing Authors By Initials

JM Hooker,A Datta,M Botta,KN Raymond,MB Francis,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nano letters

VOLUME: 7

Page Numbers: 2207-10

Journal Abbreviation: Nano Lett.

ISSN: 1530-6984

DAY: 14

MONTH: 07

YEAR: 2007

Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101088070

Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: methods

Chemical & Substance for Abstract: Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Information

Substance Name: Gadolinium

Registry Number: 7440-54-2

Grant and Affiliation Information for Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies.

AFFILIATION: Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL69832

ACRONYM: HL

MEDLINETA: Nano Lett

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