MafA regulates expression of genes important to islet beta-cell function.

MafA regulates expression of genes important to islet beta-cell function. Research Abstract Details 

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MafA regulates expression of genes important to islet beta-cell function. Abstract Text:

Taka-aki Matsuoka,Hideaki Kaneto,Roland Stein,Takeshi Miyatsuka,Dan Kawamori,Eva Henderson,Itaru Kojima,Munehide Matsuhisa,Masatsugu Hori,Yoshimitsu Yamasaki,Taka-aki Matsuoka,Hideaki Kaneto,Roland Stein,Takeshi Miyatsuka,Dan Kawamori,Eva Henderson,Itaru Kojima,Munehide Matsuhisa,Masatsugu Hori,Yoshimitsu Yamasaki,

Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet beta-cells. Here we show that ectopic expression of MafA is sufficient to induce a small amount of endogenous insulin expression in a variety of non-beta-cell lines. Insulin mRNA and protein expression was induced to a much higher level when MafA was provided with two other key insulin activators, pancreatic and duodenal homeobox (PDX-1) and BETA2. Potentiation by PDX-1 and BETA2 was entirely dependent upon MafA, and MafA binding to the insulin enhancer region was increased by PDX-1 and BETA2. Treatment with activin A and hepatocyte growth factor induced even larger amounts of insulin in AR42J pancreatic acinar cells, compared with other non-beta endodermal cells. The combination of PDX-1, BETA2, and MafA also induced the expression of other important regulators of islet beta-cell activity. These results support a critical role of MafA in islet beta-cell function.

MafA regulates expression of genes important to islet beta-cell function. Publishing Authors By Initials

TA Matsuoka,H Kaneto,R Stein,T Miyatsuka,D Kawamori,E Henderson,I Kojima,M Matsuhisa,M Hori,Y Yamasaki,TA Matsuoka,H Kaneto,R Stein,T Miyatsuka,D Kawamori,E Henderson,I Kojima,M Matsuhisa,M Hori,Y Yamasaki,

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MafA regulates expression of genes important to islet beta-cell function. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular endocrinology (Baltimore, Md.)

VOLUME: 21

Page Numbers: 2764-74

Journal Abbreviation: Mol. Endocrinol.

ISSN: 0888-8809

DAY: 17

MONTH: 07

YEAR: 2007

MafA regulates expression of genes important to islet beta-cell function. Information

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LANGUAGE: eng

NlmUniqueID: 8801431

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Grant and Affiliation Information for MafA regulates expression of genes important to islet beta-cell function.

AFFILIATION: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871 Japan. takaaki@medone.med.osaka-u.ac.jp

Country: United States

AGENCY: United States NIDDK

GRANT: DK42502

ACRONYM: DK

MEDLINETA: Mol Endocrinol

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