Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Research Abstract Details 

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Abstract Text:

Mad2 is an essential component of the spindle checkpoint that blocks activation of Separase and dissolution of sister chromatids until microtubule attachment to kinetochores is complete. We show here that overexpression of Mad2 in transgenic mice leads to a wide variety of neoplasias, appearance of broken chromosomes, anaphase bridges, and whole-chromosome gains and losses, as well as acceleration of myc-induced lymphomagenesis. Moreover, continued overexpression of Mad2 is not required for tumor maintenance, unlike the majority of oncogenes studied to date. These results demonstrate that transient Mad2 overexpression and chromosome instability can be an important stimulus in the initiation and progression of different cancer subtypes.

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Publishing Authors By Initials

For similar neoplasms research abstracts see: neoplasms research

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer cell

VOLUME: 11

Page Numbers: 9-23

Journal Abbreviation: Cancer Cell

ISSN: 1535-6108

DAY: 28

MONTH: 12

YEAR: 2006

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Information

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LANGUAGE: eng

NlmUniqueID: 101130617

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Information

Substance Name: MAD2 protein, mouse

Registry Number: 0

Grant and Affiliation Information for Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

AFFILIATION: Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA124378-08A1

ACRONYM: CA

MEDLINETA: Cancer Cell

REFSOURCE: Cancer Cell. 2007 Jan;11(1):1-3

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