Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations.

Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Research Abstract Details 

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Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Abstract Text:

Tomas S Aleman,Artur V Cideciyan,Elizabeth A M Windsor,Sharon B Schwartz,Malgorzata Swider,John D Chico,Alexander Sumaroka,Alexander Y Pantelyat,Keith G Duncan,Leigh M Gardner,Jessica M Emmons,Janet D Steinberg,Edwin M Stone,Samuel G Jacobson,

PURPOSE: To determine macular pigment (MP) optical density (OD) in patients with ABCA4-associated retinal degenerations (ABCA4-RD) and the response of MP and vision to supplementation with lutein. METHODS: Patients with Stargardt disease or cone-rod dystrophy and known or suspected disease-causing mutations in the ABCA4 gene were included. All patients had foveal fixation. MPOD profiles were measured with heterochromatic flicker photometry. Serum carotenoids, visual acuity, foveal sensitivity, and retinal thickness were quantified. Changes in MPOD and central vision were determined in a subset of patients receiving oral supplementation with lutein for 6 months. RESULTS: MPOD in patients ranged from normal to markedly abnormal. As a group, patients with ABCA4-RD had reduced foveal MPOD, and there was a strong correlation with retinal thickness. Average foveal tissue concentration of MP, estimated by dividing MPOD by retinal thickness, was normal in patients, whereas serum concentration of lutein and zeaxanthin was significantly lower than normal. After oral lutein supplementation for 6 months, 91% of the patients showed significant increases in serum lutein, and 63% of the patients' eyes showed a significant augmentation in MPOD. The retinal responders tended to be female and to have lower serum lutein and zeaxanthin, lower MPOD, and greater retinal thickness at baseline. Responding eyes had significantly lower baseline MP concentration than did nonresponding eyes. Central vision was unchanged after the period of supplementation. CONCLUSIONS: MP is strongly affected by the stage of ABCA4 disease leading to abnormal foveal architecture. MP could be augmented by supplemental lutein in some patients. There was no change in central vision after 6 months of lutein supplementation. Long-term influences of this supplement on the natural history of these macular degenerations require further study.

Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Publishing Authors By Initials

TS Aleman,AV Cideciyan,EA Windsor,SB Schwartz,M Swider,JD Chico,A Sumaroka,AY Pantelyat,KG Duncan,LM Gardner,JM Emmons,JD Steinberg,EM Stone,SG Jacobson,

For similar organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: beta carotene research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: beta carotene research

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Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Investigative ophthalmology & visual science

VOLUME: 48

Page Numbers: 1319-29

Journal Abbreviation: Invest. Ophthalmol. Vis. Sci.

ISSN: 0146-0404

DAY: 3

MONTH: Mar

YEAR: 2007

Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7703701

Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Keywords Mesh Terms:

KEYWORDS: beta Carotene

MESH TERMS: blood

Chemical & Substance for Abstract: Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations. Information

Substance Name: beta Carotene

Registry Number: 7235-40-7

Grant and Affiliation Information for Macular pigment and lutein supplementation in ABCA4-associated retinal degenerations.

AFFILIATION: Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. aleman@mail.med.upenn.edu

Country: United States

AGENCY: United States NEI

GRANT: EY13203

ACRONYM: EY

MEDLINETA: Invest Ophthalmol Vis Sci

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