Macrophages regulate the angiogenic switch in a mouse model of breast cancer.

Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Research Abstract Details 

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Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Abstract Text:

Elaine Y Lin,Jiu-Feng Li,Leoid Gnatovskiy,Yan Deng,Liyin Zhu,Dustin A Grzesik,Hong Qian,Xiao-nan Xue,Jeffrey W Pollard,

The development of a tumor vasculature or access to the host vasculature is a crucial step for the survival and metastasis of malignant tumors. Although therapeutic strategies attempting to inhibit this step during tumor development are being developed, the biological regulation of this process is still largely unknown. Using a transgenic mouse susceptible to mammary cancer, PyMT mice, we have characterized the development of the vasculature in mammary tumors during their progression to malignancy. We show that the onset of the angiogenic switch, identified as the formation of a high-density vessel network, is closely associated with the transition to malignancy. More importantly, both the angiogenic switch and the progression to malignancy are regulated by infiltrated macrophages in the primary mammary tumors. Inhibition of the macrophage infiltration into the tumor delayed the angiogenic switch and malignant transition whereas genetic restoration of the macrophage population specifically in these tumors rescued the vessel phenotype. Furthermore, premature induction of macrophage infiltration into premalignant lesions promoted an early onset of the angiogenic switch independent of tumor progression. Taken together, this study shows that tumor-associated macrophages play a key role in promoting tumor angiogenesis, an essential step in the tumor progression to malignancy.

Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Publishing Authors By Initials

EY Lin,JF Li,L Gnatovskiy,Y Deng,L Zhu,DA Grzesik,H Qian,XN Xue,JW Pollard,

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Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 66

Page Numbers: 11238-46

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 17

MONTH: 11

YEAR: 2006

Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Keywords Mesh Terms:

KEYWORDS: Receptor, Macrophage Colony-Stimulating

MESH TERMS: metabolism

Chemical & Substance for Abstract: Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Information

Substance Name: Receptor, Macrophage Colony-Stimulating

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Macrophages regulate the angiogenic switch in a mouse model of breast cancer.

AFFILIATION: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Country: United States

AGENCY: United States NCI

GRANT: P30 CA 13330

ACRONYM: CA

MEDLINETA: Cancer Res

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