Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids.

Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. Research Abstract Details 

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Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. Abstract Text:

M Vivarelli,L E D'Urbano,A Insalaco,M Lunt,F Jury,A E Tozzi,A Ravelli,A Martini,R Donn,F De Benedetti,M Vivarelli,L E D'Urbano,A Insalaco,M Lunt,F Jury,A E Tozzi,A Ravelli,A Martini,R Donn,F De Benedetti,

OBJECTIVES:To address the clinical relevance of macrophage migration inhibitory factor (MIF) promoter polymorphisms in oligoarticular juvenile idiopathic arthritis (o-JIA) by evaluating their associations with serum and SF MIF levels, with response to intra-articular glucocorticoid injections and with outcome of the disease.METHODS:Seventy-five Caucasian patients with o-JIA were studied. Alleles of the -794 CATT variable number of tandem repeats (VNTR) and of the -173 G/C single nucleotide polymorphism (SNP) were identified by capillary electrophoresis following fluorescently labelled PCR and by allelic discrimination assay, respectively. MIF levels were measured by ELISA. The association of MIF promoter polymorphisms with polyarticular extension, Childhood Health Assessment Questionnaire (CHAQ) score at the last follow-up visit and occurrence of chronic anterior uveitis was evaluated only in patients with a follow up > 5 years.RESULTS:Neither of the MIF promoter polymorphisms was associated with serum MIF levels, nor with the long-term outcome of o-JIA. The -173 G/C SNP was significantly associated with both SF MIF levels and duration of response to intra-articular glucocorticoid injection. Carriers of a MIF -173*C allele were 4 times more likely to relapse within 3 months. No association was found between the different MIF CATT alleles and both SF MIF levels and duration of response to intra-articular glucocorticoids.CONCLUSION:Our study shows the clinical relevance of the MIF -173 G/C SNP in o-JIA and suggests that the -173*C allele may represent a predictor of poor response to intra-articular glucocorticoid treatment.

Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. Publishing Authors By Initials

M Vivarelli,LE D'Urbano,A Insalaco,M Lunt,F Jury,AE Tozzi,A Ravelli,A Martini,R Donn,F De Benedetti,M Vivarelli,LE D'Urbano,A Insalaco,M Lunt,F Jury,AE Tozzi,A Ravelli,A Martini,R Donn,F De Benedetti,

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PUBMED ID PMID:

MEDLINE DATE: 2007 Sep-Oct

Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental rheumatology

VOLUME: 25

Page Numbers: 775-81

Journal Abbreviation: Clin. Exp. Rheumatol.

ISSN: 0392-856X

DAY: 14

MONTH: 12

YEAR: 2007

Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. Information

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LANGUAGE: eng

NlmUniqueID: 8308521

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AFFILIATION: Direzione Scientifica, Pediatria II Reumatologia, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

Country: Italy

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MEDLINETA: Clin Exp Rheumatol

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