Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus.

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. Abstract Text:

Peter J Gaskill,Michelle Zandonatti,Tim Gilmartin,Steven R Head,Howard S Fox,Peter J Gaskill,Michelle Zandonatti,Tim Gilmartin,Steven R Head,Howard S Fox,Peter J Gaskill,Michelle Zandonatti,Tim Gilmartin,Steven R Head,Howard S Fox,

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. Publishing Authors By Initials

PJ Gaskill,M Zandonatti,T Gilmartin,SR Head,HS Fox,PJ Gaskill,M Zandonatti,T Gilmartin,SR Head,HS Fox,PJ Gaskill,M Zandonatti,T Gilmartin,SR Head,HS Fox,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of virology

VOLUME: 82

Page Numbers: 1615-21

Journal Abbreviation: J. Virol.

ISSN: 1098-5514

DAY: 28

MONTH: 11

YEAR: 2007

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus.

AFFILIATION: The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2030, La Jolla, CA 92037. hsfox@scripps.edu.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus Related Publications

• Absolute linearity measurements on HgCdTe detectors in the infrared region.
• Cognitive functioning in excessive drinkers: evidence for dissociable impairments.
• Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay.
• Computational Neuronal Oscillations using Morlet Wavelet Transform.
• Diastereoselective synthesis of methylenecyclopropanes from chiral cyclopropene derivatives.
• Enantioselective, facially selective carbomagnesation of cyclopropenes.
• Enterohepatic Helicobacter species isolated from the ileum, liver and colon of a baboon with pancreatic islet amyloidosis.
• Evaluation of protein fractionation systems used in formulating rations for dairy cattle.
• Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer.
• Identification of Rv3230c as the NADPH oxidoreductase of a two-protein DesA3 acyl-CoA desaturase in Mycobacterium tuberculosis H37Rv.
• Interleukin-17 as a molecular target in immune-mediated arthritis: immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4.
• Issues in estimating the prevalence of fetal alcohol syndrome: examination of 2 counties in New York State.
• MR imaging volumetry of subcortical structures and cerebellar hemispheres in temporal lobe epilepsy.
• Outcomes from a group intervention for coping with HIV/AIDS and childhood sexual abuse: reductions in traumatic stress.
• Prolonged survival of porcine hepatocytes in cynomolgus monkeys.
• Rapid discrimination of Bacillus anthracis from other members of the B. cereus group by mass and sequence of "intact" small acid soluble proteins (SASPs) using mass spectrometry.
• Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora.
• Regulatory T cell defects in rheumatoid arthritis.
• Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging.
• Retrospective motion correction protocol for high-resolution anatomical MRI.
• Rh-catalyzed intermolecular reactions of alkynes with alpha-diazoesters that possess beta-hydrogens: ligand-based control over divergent pathways.
• Simian immunodeficiency virus-induced CD4+ T cell deficits in cytokine secretion profile are dependent on monkey origin.
• Synthesis of cyclopropene alpha-amino acids via enantioselective desymmetrization.
• The role of infant soothability in the relation between infant negativity and maternal sensitivity.
• The sociobiologic integrative model (SBIM): enhancing the integration of sociobehavioral, environmental, and biomolecular knowledge in urban health and disparities research.
• The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.
• Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p.
• Translational control of ceruloplasmin gene expression: beyond the IRE.
• Using the Price Equation to partition the effects of biodiversity loss on ecosystem function.
• Variation in caregiver perceptions of teamwork climate in labor and delivery units.