Macrophage-derived growth factor for osteoblast-like cells and chondrocytes.

Macrophage-derived growth factor for osteoblast-like cells and chondrocytes. Research Abstract Details 

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Macrophage-derived growth factor for osteoblast-like cells and chondrocytes. Abstract Text:

L Rifas,V Shen,K Mitchell,W A Peck,

Rat resident peritoneal macrophages in primary culture were found to elaborate a mitogenic factor (or factors) for rat osteoblast-like cells and chondrocytes but not for skin fibroblasts. Growth-promoting activity appeared in the incubation medium within the first 20 hr of macrophage culture and was released in amounts that paralleled the number of macrophages per culture. After their proliferative response, as judged by increases in DNA synthesis and cell number, the osteoblast-like cells became enriched in alkaline phosphatase, an index of osteoblast specialization. The macrophage-derived activity was nondialyzable and heat-stable, and it was eliminated by exposure to trypsin. Inhibition of prostaglandin cyclooxygenase failed to modify its generation. Partial purification (Amicon filter concentration, gel filtration) disclosed principal peaks of activity corresponding to Mr of 43,000 and 10,000. The crude conditioned medium and the Mr 43,000-peak, but not the low-molecular-weight peak, exhibited interleukin 1 activity, as judged by the ability to stimulate the proliferation of mouse thymic lymphocytes. The macrophage-derived growth factor described herein may participate in bone remodeling and repair and in primary bone and cartilage growth.

Macrophage-derived growth factor for osteoblast-like cells and chondrocytes. Publishing Authors By Initials

L Rifas,V Shen,K Mitchell,WA Peck,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

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Macrophage-derived growth factor for osteoblast-like cells and chondrocytes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 81

Page Numbers: 4558-62

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 18

MONTH: Jul

YEAR: 1984

Macrophage-derived growth factor for osteoblast-like cells and chondrocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Macrophage-derived growth factor for osteoblast-like cells and chondrocytes. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Macrophage-derived growth factor for osteoblast-like cells and chondrocytes. Information

Substance Name: Indomethacin

Registry Number: 53-86-1

Grant and Affiliation Information for Macrophage-derived growth factor for osteoblast-like cells and chondrocytes.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NIADDK

GRANT: AM19855-07

ACRONYM: AM

MEDLINETA: Proc Natl Acad Sci U S A

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