Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes.

Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. Research Abstract Details 

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Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. Abstract Text:

H Hayashi,I Kudo,K Inoue,H Nomura,S Nojima,

The phospholipid mediator, platelet activating factor (PAF: 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine), was recently reported to activate macrophage-monocyte cells as well as neutrophils or platelets. PAF was incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes, and their effect on guinea pig peritoneal macrophages was examined. PAF incorporated into liposomes was found to activate macrophages much more potently than PAF in the free form, whereas the effect of PAF in liposome on platelets was weaker than that of PAF in the free form. A large difference between PAF in liposomes and PAF in the free form was observed in the rate of degradation of PAF during incubation with macrophages. This rapid degradation of PAF in the free form may partially explain the poor activation by PAF of macrophages.

Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. Publishing Authors By Initials

H Hayashi,I Kudo,K Inoue,H Nomura,S Nojima,

For similar organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research abstracts see: organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research

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Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 97

Page Numbers: 1255-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Apr

YEAR: 1985

Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. Keywords Mesh Terms:

KEYWORDS: Serotonin

MESH TERMS: secretion

Chemical & Substance for Abstract: Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes.

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Country: JAPAN

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MEDLINETA: J Biochem

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