Pyruvate Dehydrogenase Complex

"A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phoshorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology

Dihydrolipoyllysine-Residue Acetyltransferase Research

Pyruvate Dehydrogenase (Lipoamide) Research

Abstracts

- Developmental cardiac metabolism in health and disease. Cardiac metabolism changes in response to oxygen and substrate availability during development. The fetus is relatively more dependent on anaerobic...

- Effect of nitrate reduction on the enzyme levels in carbon metabolism in Escherichia coli. The activities of twelve enzymes were measured in crude extracts from cells of Escherichia coli K-10 grown aerobically or anaerobically in a defined medium...

- Insights into the role of anaplerosis in insulin secretion: A 13C NMR study. AIMS/HYPOTHESIS: Defining mechanisms and enzymatic paths critical to fuel-regulated insulin secretion are key goals of diabetes research. In this study,...

- Is primary biliary cirrhosis an autoimmune disease? This review summarizes the experimental and clinical support for an autoimmune origin of primary biliary cirrhosis (PBC). Direct proof is lacking, but...

- Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis. Pyruvate dehydrogenase found in mitochondria of Euglena gracilis was active on NADP+ but not NAD+, and FAD and methyl viologen also served as electron...

- The biochemical basis of the relation between glucose and fatty acid metabolism.

- Turnover of pegeon breast muscle pyruvate dehydrogenase complex. The pigeon breast muscle pyruvate dehydrogenase complex was resolved into three component enzymes: lipoate acetyltransferase, pyruvate dehydrogenase, and...