Lysyl oxidase: an oxidative enzyme and effector of cell function.

Lysyl oxidase: an oxidative enzyme and effector of cell function. Research Abstract Details 

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Lysyl oxidase: an oxidative enzyme and effector of cell function. Abstract Text:

H A Lucero,H M Kagan,

Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine residues to residues of alpha-aminoadipic-delta-semialdehyde. This posttranslational chemical change permits the covalent crosslinking of the component chains of collagen and those of elastin, thus stabilizing the fibrous deposits of these proteins in the extracellular matrix. Four LOX-like (LOXL) proteins with varying degrees of similarity to LOX have been described, constituting a family of related proteins. LOX is synthesized as a preproprotein which emerges from the cell as proLOX and then is processed to the active enzyme by proteolysis. In addition to elastin and collagen, LOX can oxidize lysine within a variety of cationic proteins, suggesting that its functions extend beyond its role in the stabilization of the extracellular matrix. Indeed, recent findings reveal that LOX and LOXL proteins markedly influence cell behavior including chemotactic responses, proliferation, and shifts between the normal and malignant phenotypes.

Lysyl oxidase: an oxidative enzyme and effector of cell function. Publishing Authors By Initials

HA Lucero,HM Kagan,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research

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Lysyl oxidase: an oxidative enzyme and effector of cell function. Journal Published:

PUBLICATION TYPE: Review

Journal: Cellular and molecular life sciences : CMLS

VOLUME: 63

Page Numbers: 2304-16

Journal Abbreviation: Cell. Mol. Life Sci.

ISSN: 1420-682X

DAY: 3

MONTH: Oct

YEAR: 2006

Lysyl oxidase: an oxidative enzyme and effector of cell function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9705402

Lysyl oxidase: an oxidative enzyme and effector of cell function. Keywords Mesh Terms:

KEYWORDS: Substrate Specificity

MESH TERMS: physiology

Chemical & Substance for Abstract: Lysyl oxidase: an oxidative enzyme and effector of cell function. Information

Substance Name: Protein-Lysine 6-Oxidase

Registry Number: EC 1.4.3.13

Grant and Affiliation Information for Lysyl oxidase: an oxidative enzyme and effector of cell function.

AFFILIATION: Department of Biochemistry, Boston University School of Medicine, 715 Albany St., Boston, Massachusetts 02118, USA.

Country: Switzerland

AGENCY: United States NIAMS

GRANT: R37 AR 18880

ACRONYM: AR

MEDLINETA: Cell Mol Life Sci

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