Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1).

Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1). Research Abstract Details 

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Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1). Abstract Text:

Shinya Shano,Ryutaro Moriyama,Jerold Chun,Nobuyuki Fukushima,

Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions through multiple types of LPA receptors. Here we explore the role of LPA receptor subtypes in cortical astrocyte functions. Astrocytes cultured under serum-free conditions were found to express the genes of five LPA receptor subtypes, lpa(1) to lpa(5). When astrocytes were treated with dibutyryl cyclic adenosine monophosphate, a reagent inducing astrocyte differentiation or activation, lpa(1) expression levels remained unchanged, but those of other LPA receptor subtypes were relatively reduced. LPA stimulated DNA synthesis in both undifferentiated and differentiated astrocytes, but failed to do so in astrocytes prepared from mice lacking lpa(1) gene. LPA also inhibited [(3)H]-glutamate uptake in both undifferentiated and differentiated astrocytes; and LPA-induced inhibition of glutamate uptake was still observed in lpa(1)-deficient astrocytes. Taken together, these observations demonstrate that LPA(1) mediates LPA-induced stimulation of cell proliferation but not inhibition of glutamate uptake in astrocytes.

Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1). Publishing Authors By Initials

S Shano,R Moriyama,J Chun,N Fukushima,

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Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurochemistry international

VOLUME: 52

Page Numbers: 216-20

Journal Abbreviation: Neurochem. Int.

ISSN: 0197-0186

DAY: 10

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 8006959

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AFFILIATION: Division of Molecular Neurobiology, Department of Life Sciences, School of Science and Engineering, Kinki University, Kowakae 3-4-1, Higashiosaka 577-8502, Japan.

Country: England

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MEDLINETA: Neurochem Int

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