Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells.

Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells. Abstract Text:

Reiko Adachi,Kazuhiro Suzuki,

We have investigated the contribution of Hck, Lyn and Fgr, highly expressed Src family tyrosine kinases (SFKs) in signalling pathways in opsonized zymosan (OZ)-activated phagocytes by using short interfering RNAs (siRNAs). Treatment of macrophage-like U937 cells with the siRNAs targeted to these transcripts decreased the protein content of each kinase to less than half that of untreated cells. Among these siRNAs, siRNA targeted to Lyn was the most effective in diminishing two kinds of phagocyte functions, that is oxidative burst and phagocytosis. Phosphorylation of c-Cbl, a multidomain adaptor protein in the beta2 integrin-signalling pathway, was also largely inhibited by treatment with siRNA to Lyn. Thus, the results with siRNAs highly specific for Hck, Lyn and Fgr suggested that, among these three SFKs, Lyn plays the most important role in signalling pathways downstream of beta2 integrins in OZ-stimulated phagocytes.

Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells. Publishing Authors By Initials

R Adachi,K Suzuki,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: src-family kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: src-family kinases research

PUBMED ID PMID:

MEDLINE DATE:

Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell biochemistry and function

VOLUME: 25

Page Numbers: 323-33

Journal Abbreviation:

ISSN: 0263-6484

DAY: 20

MONTH: 11

YEAR: 2007

Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8305874

Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells. Keywords Mesh Terms:

KEYWORDS: src-Family Kinases

MESH TERMS: drug effects

Chemical & Substance for Abstract: Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells. Information

Substance Name: Proto-Oncogene Proteins c-cbl

Registry Number: EC 6.3.2.-

Grant and Affiliation Information for Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells.

AFFILIATION: Division of Biosignaling, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan. akasaka@nihs.go.jp

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Biochem Funct

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells Related Publications

• A uniformly cleaved epitaxically grown diamond crystal for synchrotron radiation.
• Absolute soft X-ray measurements using an ion chamber.
• Agmatine suppresses mesangial cell proliferation by modulating polyamine metabolism.
• Attention induces synchronization-based response gain in steady-state visual evoked potentials.
• Behavior of Medaka fish under distributed gravity.
• Branched-chain amino acid supplementation during the endoscopic injection sclerotherapy for esophageal varices may be useful for maintenance of nutritional status in patients with liver cirrhosis.
• Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center.
• Cytokine production of CD8+ immune T cells but not of CD4+ T cells from Toxoplasma gondii-infected mice is polarized to a type 1 response following stimulation with tachyzoite-infected macrophages.
• Developmental capacity of bovine oocytes cryopreserved after maturation in vitro and of frozen-thawed bovine embryos derived from frozen mature oocytes.
• Developmental capacity of bovine oocytes frozen in different cryoprotectants.
• Effects of different lots of semen from the same bull on in vitro development of bovine oocytes fertilized in vitro.
• Effects of pressure on the phase transition of bilayers in liposomes. Influence of cholesterol and alpha-tocopherol.
• Elevated extracellular calcium stimulates secretion of bone morphogenetic protein 2 by a macrophage cell line.
• Expression of bHLH Transcription Factors and IGFs in the Non-sensory Patches, Olfactory Epithelium and Vomeronasal Organ.
• Fasting plasma ghrelin levels reflect malnutrition state in patients with liver cirrhosis.
• Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma.
• Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.
• Improvement in cognitive function after radical excision of an anterior skull base meningioma - a report of 2 cases.
• Independent representation of parts and the relations between them: evidence from integrative agnosia.
• Prognosis-predicting equations using histological scores contribute to the choice of steroid therapy in IgA nephropathy: Multivariate analysis on 275 adult patients.
• Proteome analysis of glial cells treated by radiation or hydroperoxide.
• Relationship between progesterone and estradiol contents of follicular fluid and the morphological appearance of granulosa cells of follicles coexisting with corpora lutea in bovine ovaries.
• Safety of ablation of the sigmoid and transverse sinuses: an experimental study.
• Species specific differences in the ratio of short to long loop nephrons in the kidneys of laboratory rodents.
• Superovulation in the cow with a single intramuscular injection of FSH dissolved in polyvinylpyrrolidone.
• Synergism between a mycoreovirus and a hypovirus mediated by the papain-like protease p29 of the prototypic hypovirus CHV1-EP713.
• The A-site finger in 23 S rRNA acts as a functional attenuator for translocation.
• Viability of frozen-thawed bovine IVM/IVF embryos in relation to aging using various cryoprotectants.
• [High performance liquid chromatographic determination of reducing sugars in fruit juices with laser resonance Raman detection]
• [Selective extraction of organotin from biological sample by supercritical fluid extraction]