Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease.

Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Research Abstract Details 

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Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Abstract Text:

Yoshinobu Maeda,Isao Tawara,Takanori Teshima,Chen Liu,Daigo Hashimoto,Ken-Ichi Matsuoka,Mitsune Tanimoto,Pavan Reddy,

OBJECTIVE: T cells that undergo lymphopenia-induced proliferation (LIP) are characterized by greater effector and anti-tumor function than naïve T cells. But the ability of these T cells in causing graft-versus-host disease (GVHD) is not known. METHODS: We tested the hypothesis that donor T cells that had undergone LIP would cause more severe GVHD than naïve T cells by utilizing well-characterized murine experimental models of allogeneic bone marrow transplantation (BMT). RESULTS: Contrary to our hypothesis, LIP of donor T cells under either noninflammatory or irradiated conditions caused significantly reduced GVHD as determined by survival, clinical, pathologic, and biochemical parameters than naïve T cells. Compared to naïve donor T cells, LIP T cells demonstrated reduced expansion in vivo and in vitro after allogeneic BMT. The reduction in GVHD mortality and severity was observed across multiple strains after allogeneic BMT. In vivo mechanistic studies by cell depletion demonstrated an increase in the CD44(hi) "memory" phenotype T cells and not the CD4(+)CD25(+) T cell subset to be critical for the reduction in GVHD. CONCLUSIONS: These data demonstrate that LIP of T cells regulates acute GVHD severity in contrast to their ability to cause increased allograft rejection, autoimmunity, or anti-tumor immunity.

Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Publishing Authors By Initials

Y Maeda,I Tawara,T Teshima,C Liu,D Hashimoto,K Matsuoka,M Tanimoto,P Reddy,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

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Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental hematology

VOLUME: 35

Page Numbers: 274-86

Journal Abbreviation: Exp. Hematol.

ISSN: 0301-472X

DAY: 30

MONTH: Feb

YEAR: 2007

Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Information

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LANGUAGE: eng

NlmUniqueID: 402313

Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: transplantation

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Grant and Affiliation Information for Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease.

AFFILIATION: Department of Medicine, Okayama University, Okayama, Japan.

Country: Netherlands

AGENCY: United States NIAID

GRANT: K08 AI052863-01

ACRONYM: AI

MEDLINETA: Exp Hematol

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