Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.

Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. Research Abstract Details 

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Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. Abstract Text:

Jiali Li,Wenru Song,Debra K Czerwinski,Bindu Varghese,Satoshi Uematsu,Shizuo Akira,Arthur M Krieg,Ronald Levy,

Established widely metastatic tumor was cured in a transplanted mouse B cell lymphoma model, by the combination of chemotherapy plus intratumoral injection of oligodeoxynucleotides containing unmethylated C-G motifs (CpG). This therapeutic effect required that the CpG be injected directly into the tumor and was dependent on CD8 T cells. Although the efficacy of CpG oligodeoxynucleotides has been thought to depend on the expression of TLR9, we unexpectedly found that tumor rejection did not require host expression of TLR9. By using a TLR9-deficient tumor and a TLR9KO host, we demonstrate that TLR9 expression either by the host or the tumor is required. These results indicate that activation of Ag presentation by cells within the tumor via TLR9 stimulation can be an effective form of immunotherapy. This study forms the basis of an ongoing clinical trial in patients with lymphoma.

Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. Publishing Authors By Initials

J Li,W Song,DK Czerwinski,B Varghese,S Uematsu,S Akira,AM Krieg,R Levy,

For similar proteins: dna-binding proteins: toll-like receptor 9 research abstracts see: proteins: dna-binding proteins: toll-like receptor 9 research

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Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 2493-500

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Aug

YEAR: 2007

Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. Keywords Mesh Terms:

KEYWORDS: Toll-Like Receptor 9

MESH TERMS: immunology

Chemical & Substance for Abstract: Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. Information

Substance Name: Toll-Like Receptor 9

Registry Number: 0

Grant and Affiliation Information for Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.

AFFILIATION: Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA34233

ACRONYM: CA

MEDLINETA: J Immunol

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