Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix.

Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Research Abstract Details 

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Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Abstract Text:

Adhemar Longatto-Filho, Pinheiro, Pereira,Daniela Etlinger,Marise A R Moreira,Luiz Fernando ,Geraldo Silva Queiroz, Baltazar,Fernando C Schmitt,

OBJECTIVE: We sought to determine the significance of lymphatic vessel density (LVD) in pre-malignant lesions and carcinomas of the uterine cervix and to evaluate the prognostic value of lymphatic invasion and D2-40 positivity in tumor cells in the three histological types of invasive lesions. The correlation of LVD, lymphatic invasion and D2-40 positivity in tumor cells with EGFR and COX-2 expressions was also evaluated. METHODS: We studied 50 cervicitis, 50 low-grade squamous intraepithelial lesions (LSIL) (CIN1), 51 high-grade squamous intraepithelial lesions (HSIL) (CIN2/CIN3), 49 invasive squamous cells carcinomas (SCC), 43 adenocarcinomas (AC) and 30 adenosquamous cells carcinomas (ASC). The immunoreaction assay was performed using the monoclonal antibody D2-40. RESULTS: Significant differences in LVD were found among all categories of pre-invasive and invasive lesions (p=0.001 and p<0.001, respectively). LVD in invasive lesions was significantly greater than in pre-invasive lesions (p<0.001) and no significant association was found between LVD in invasive lesions and both lymph node invasion and/or metastasis. D2-40 positivity in tumor cells was associated with a better prognosis in ASC cases. EGFR and COX-2 expressions in invasive lesions were not associated with LVD; however, they correlated with both lymphatic invasion and D2-40 positivity in tumor cells. CONCLUSIONS: Lymphatic neovascularization begins early in intraepithelial lesions and continues to increase towards malignancy. Both lymphatic invasion and decrease in D2-40 expression in tumor cells appear to have a prognostic value.

Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Publishing Authors By Initials

A Longatto-Filho,C Pinheiro,SM Pereira,D Etlinger,MA Moreira,LF ,GS Queiroz,F Baltazar,FC Schmitt,

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Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gynecologic oncology

VOLUME: 107

Page Numbers: 45-51

Journal Abbreviation: Gynecol. Oncol.

ISSN: 0090-8258

DAY: 2

MONTH: 07

YEAR: 2007

Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Information

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LANGUAGE: eng

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AFFILIATION: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal. longatto@ecsaude.uminho.pt

Country: United States

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MEDLINETA: Gynecol Oncol

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