Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation.

Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Research Abstract Details 

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Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Abstract Text:

Minnie Hsieh,Daekee Lee,Sara Panigone,Kathleen Horner,Ruby Chen,Alekos Theologis,David C Lee,David W Threadgill,Marco Conti,

In the preovulatory ovarian follicle, mammalian oocytes are maintained in prophase meiotic arrest until the luteinizing hormone (LH) surge induces reentry into the first meiotic division. Dramatic changes in the somatic cells surrounding the oocytes and in the follicular wall are also induced by LH and are necessary for ovulation. Here, we provide genetic evidence that LH-dependent transactivation of the epidermal growth factor receptor (EGFR) is indispensable for oocyte reentry into the meiotic cell cycle, for the synthesis of the extracellular matrix surrounding the oocyte that causes cumulus expansion, and for follicle rupture in vivo. Mice deficient in either amphiregulin or epiregulin, two EGFR ligands, display delayed or reduced oocyte maturation and cumulus expansion. In compound-mutant mice in which loss of one EGFR ligand is associated with decreased signaling from a hypomorphic allele of the EGFR, LH no longer signals oocyte meiotic resumption. Moreover, induction of genes involved in cumulus expansion and follicle rupture is compromised in these mice, resulting in impaired ovulation. Thus, these studies demonstrate that LH induction of epidermal growth factor-like growth factors and EGFR transactivation are essential for the regulation of a critical physiological process such as ovulation and provide new strategies for manipulation of fertility.

Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Publishing Authors By Initials

M Hsieh,D Lee,S Panigone,K Horner,R Chen,A Theologis,DC Lee,DW Threadgill,M Conti,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular biology

VOLUME: 27

Page Numbers: 1914-24

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 28

MONTH: 12

YEAR: 2006

Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Information

Substance Name: Luteinizing Hormone

Registry Number: 9002-67-9

Grant and Affiliation Information for Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation.

AFFILIATION: Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5317, USA.

Country: United States

AGENCY: United States NICHD

GRANT: U54-HD31389

ACRONYM: HD

MEDLINETA: Mol Cell Biol

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