Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood.

Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood. Research Abstract Details 

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Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood. Abstract Text:

Mycoplasma (M.) pneumoniae has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection with M. pneumoniae in early childhood has a long-term influence on lung function and bronchial responsiveness. In a retrospective, clinical cohort-study children younger than 5 years-of-age when PCR-tested for M. pneumoniae were enrolled. Sixty-five children with clinical symptoms suggesting infection with M. pneumoniae during an epidemic season completed a clinical follow-up examination including lung function testing (28 PCR-positive and 37 PCR-negative). In addition to the PCR-test for M. pneumoniae all respiratory tract specimens were additionally tested for other atypical bacteria and for viruses by PCR. Lung function was measured as specific airway resistance by whole-body plethysmography and bronchial hyperresponsiveness was assessed by cold, dry air hyperventilation. Neither baseline lung function nor bronchial response to cold dry air hyperventilation differed between M. pneumoniae-positive and -negative children: mean baseline lung function were 1.17 versus 1.21 (kPa sec), P = 0.45; and mean change in specific resistance was 13% versus 9%, P = 0.42. In conclusion, M. pneumoniae infection in early childhood was not associated with long-term effects on lung function and bronchial hyperresponsiveness 2 years after infection.

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Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric pulmonology

VOLUME: 43

Page Numbers: 567-75

Journal Abbreviation: Pediatr. Pulmonol.

ISSN: 1099-0496

DAY: 5

MONTH: Jun

YEAR: 2008

Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood.

AFFILIATION: Department of Paediatrics, Copenhagen University Hospital, Glostrup, Denmark. bbk@dadlnet.dk

Country: United States

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MEDLINETA: Pediatr Pulmonol

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