Lung cancer incidence in never smokers.

Lung cancer incidence in never smokers. Research Abstract Details 

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Lung cancer incidence in never smokers. Abstract Text:

PURPOSE: Lung cancer is a leading cause of cancer death worldwide. Although smoking remains the predominant cause of lung cancer, lung cancer in never smokers is an increasingly prominent public health issue. However, data on this topic, particularly lung cancer incidence rates in never smokers, are limited. METHODS: We reviewed the existing literature on lung cancer incidence and mortality rates among never smokers and present new data regarding rates in never smokers from the following large, prospective cohorts: Nurses' Health Study; Health Professionals Follow-Up Study; California Teachers Study; Multiethnic Cohort Study; Swedish Lung Cancer Register in the Uppsala/Orebro region; and First National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study. RESULTS: Truncated age-adjusted incidence rates of lung cancer among never smokers age 40 to 79 years in these six cohorts ranged from 14.4 to 20.8 per 100,000 person-years in women and 4.8 to 13.7 per 100,000 person-years in men, supporting earlier observations that women are more likely than men to have non-smoking-associated lung cancer. The distinct biology of lung cancer in never smokers is apparent in differential responses to epidermal growth factor receptor inhibitors and an increased prevalence of adenocarcinoma histology in never smokers. CONCLUSION: Lung cancer in never smokers is an important public health issue, and further exploration of its incidence patterns, etiology, and biology is needed.

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Lung cancer incidence in never smokers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical oncology : official journal of

VOLUME: 25

Page Numbers: 472-8

Journal Abbreviation: J. Clin. Oncol.

ISSN: 1527-7755

DAY: 10

MONTH: Feb

YEAR: 2007

Lung cancer incidence in never smokers. Information

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LANGUAGE: eng

NlmUniqueID: 8309333

Lung cancer incidence in never smokers. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

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Grant and Affiliation Information for Lung cancer incidence in never smokers.

AFFILIATION: Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, USA. hwakelee@stanford.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA77398

ACRONYM: CA

MEDLINETA: J Clin Oncol

REFSOURCE: J Clin Oncol. 2007 Feb 10;25(5):469-71

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