Lucky 13-microtubule depolymerisation by kinesin-13 motors.

Lucky 13-microtubule depolymerisation by kinesin-13 motors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lucky 13-microtubule depolymerisation by kinesin-13 motors. Abstract Text:

Carolyn A Moores,Ronald A Milligan,

The kinesin-13 class of motors catalyses microtubule depolymerisation by bending tubulins at microtubule ends. Depolymerisation activity is intrinsic to the kinesin-13 motor core but the activity of the core alone is very low compared with that of constructs that also contain a conserved neck sequence. The full-length dimeric motor is an efficient depolymeriser and also diffuses along the microtubule lattice, which helps it to find microtubule ends. Current evidence supports the idea of a generic mechanism for kinesin-13-catalysed depolymerisation. However, the activity of kinesin-13 motors is precisely localised and regulated in vivo to enable a wide range of cellular roles. The proteins are involved in global control of microtubule dynamics. They also localise to mitotic and meiotic spindles, where they contribute to formation and maintenance of spindle bipolarity, chromosomal congression, attachment correction and chromatid separation. In interphase cells, intricate and subtle mechanisms appear to allow kinesin-13 motors to act on specific populations of microtubules. Such carefully controlled localisation and regulation makes these kinesins efficient, multi-tasking molecular motors.

Lucky 13-microtubule depolymerisation by kinesin-13 motors. Publishing Authors By Initials

CA Moores,RA Milligan,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Lucky 13-microtubule depolymerisation by kinesin-13 motors. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of cell science

VOLUME: 119

Page Numbers: 3905-13

Journal Abbreviation:

ISSN: 0021-9533

DAY: 1

MONTH: Oct

YEAR: 2006

Lucky 13-microtubule depolymerisation by kinesin-13 motors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 52457

Lucky 13-microtubule depolymerisation by kinesin-13 motors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Lucky 13-microtubule depolymerisation by kinesin-13 motors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Lucky 13-microtubule depolymerisation by kinesin-13 motors.

AFFILIATION: School of Crystallography, Birkbeck College, Malet Street, London, WC1E 7HX, UK. c.moores@mail.cryst.bbk.ac.uk

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Cell Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lucky 13-microtubule depolymerisation by kinesin-13 motors Related Publications

• A simple approach to test for interaction between intervention and an individual-level variable in community randomized trials.
• An instrument to level tissue in paraffin embedding.
• Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c.
• Antibodies that identify only the active conformation of Gi family G protein {alpha} subunits.
• Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms.
• Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.
• CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.
• Cannabinoids for the treatment of neuropathic pain: Clinical evidence.
• Chemical methods in the evaluation of human contamination.
• Constitutive Activity of the Cannabinoid CB1 Receptor Regulates the Function of Co-expressed Mu Opioid Receptors.
• Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon.
• Epizootiology of trypanosomiases: some aspects of mathematical modelling.
• Exogenous Hsc70, but not thermal preconditioning, confers protection to motoneurons subjected to oxidative stress.
• G protein coupling and ligand selectivity of the D2L and D3 dopamine receptors.
• G-protein-coupled receptors: an update.
• In vitro methods to prepare astrocyte and motoneuron cultures for the investigation of potential in vivo interactions.
• Lucky 13-microtubule depolymerisation by kinesin-13 motors.
• Mallory-Weiss syndrome with esophageal obstruction secondary to adherent intraluminal thrombus.
• Maternal employment, breastfeeding, and health: Evidence from maternity leave mandates.
• Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta(2)-adrenoceptor and the ERK1/2 MAPKs: implications for beta(2)-adrenoceptor signalling via the ERK1/2 MAPKs.
• New aspects of g-protein-coupled receptor signalling and regulation.
• Reactivity of DNA guanyl radicals with phenolate anions.
• Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases.
• Some determinants of attrition in prospective studies on aging.
• The patient's point of view.
• Treatment of psychoneurosis; modified CO2 abreactive technique.
• Urology in a modern health centre.
• Visualisation of a kinesin-13 motor on microtubule end mimics.
• Warburg (HARD +/- E) syndrome without retinal dysplasia: case report and review.
• c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons.