LspA-independent action of globomycin on Mycobacterium tuberculosis.

LspA-independent action of globomycin on Mycobacterium tuberculosis. Research Abstract Details 

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LspA-independent action of globomycin on Mycobacterium tuberculosis. Abstract Text:

Niaz Banaiee,William R Jacobs,Joel D Ernst,

OBJECTIVES: The objective of this study was to investigate the antimicrobial activity and specificity of globomycin, an inhibitor of lipoprotein signal peptidase II (LspA), against Mycobacterium tuberculosis. METHODS: The mycobactericidal and mycobacteriostatic activity of globomycin was determined by optical density and cfu plating. The specificity of globomycin was determined by western immunoblotting using anti-MPT83 antibody. RESULTS: Globomycin is mycobactericidal at concentrations>or=40 mg/L. However, at 80 mg/L, the processing of the lipoprotein MPT-83 is unaffected and growth-inhibitory effect of globomycin is unchanged in an lspA null mutant (DeltalspA::lspAmut) lacking the putative drug target. CONCLUSIONS: Globomycin kills M. tuberculosis through a mechanism that is independent of LspA.

LspA-independent action of globomycin on Mycobacterium tuberculosis. Publishing Authors By Initials

N Banaiee,WR Jacobs,JD Ernst,

For similar chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: enzyme inhibitors: protease inhibitors research abstracts see: chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: enzyme inhibitors: protease inhibitors research

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MEDLINE DATE:

LspA-independent action of globomycin on Mycobacterium tuberculosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of antimicrobial chemotherapy

VOLUME: 60

Page Numbers: 414-6

Journal Abbreviation: J. Antimicrob. Chemother.

ISSN: 0305-7453

DAY: 19

MONTH: 06

YEAR: 2007

LspA-independent action of globomycin on Mycobacterium tuberculosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7513617

LspA-independent action of globomycin on Mycobacterium tuberculosis. Keywords Mesh Terms:

KEYWORDS: Protease Inhibitors

MESH TERMS: pharmacology

Chemical & Substance for Abstract: LspA-independent action of globomycin on Mycobacterium tuberculosis. Information

Substance Name: signal peptidase II

Registry Number: EC 3.4.23.36

Grant and Affiliation Information for LspA-independent action of globomycin on Mycobacterium tuberculosis.

AFFILIATION: Department of Medicine (Division of Infectious Diseases), NYU School of Medicine, New York, NY 10016, USA. nbanaiee@stanford.edu

Country: England

AGENCY: United States NIAID

GRANT: R01 AI46097

ACRONYM: AI

MEDLINETA: J Antimicrob Chemother

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