Lower urinary tract symptoms (LUTS) and bladder afferent activity.

Lower urinary tract symptoms (LUTS) and bladder afferent activity. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lower urinary tract symptoms (LUTS) and bladder afferent activity. Abstract Text:

Naoki Yoshimura,Naoki Yoshimura,

AIMS: Dysregulation of bladder afferent activity and detrusor smooth muscle behavior leads to a constellation of lower urinary tract symptoms (LUTS), which includes overactive bladder (OAB). Current treatments for LUTS are poorly tolerated and may be associated with substantial adverse effects. METHODS: Major advances in the understanding of bladder neuroanatomy and the role of bladder afferent pathways in symptom generation suggest a range of targets for new therapeutic agents. RESULTS: A sensory role for urothelial and suburothelial structures has been established, as well as a cascade of afferent bladder signaling involving the bladder epithelium and detrusor muscle. Numerous inhibitory and stimulatory neurotransmitters and chemical mediators interact with a variety of specialized receptors and participate in signal transduction leading to wider neuroactivation. The blockade of muscarinic receptors, possibly mediated by muscarinic 2 (M(2)) receptors residing in the urothelium, has been shown to affect bladder afferent fibers, challenging the traditional concept that antimuscarinic therapy involves M(3) receptor-mediated effects on detrusor smooth muscle. The propagation of impulses to spinal and higher centers utilizes axonal fiber tracts remarkable for their morphologic and functional plasticity as bladder function becomes increasingly disordered. CONCLUSIONS: These findings suggest that the etiology of LUTS includes enhanced, dysregulated, and perhaps maladaptive sensory signaling arising from numerous pelvic locales, including the most superficial epithelium of the bladder.

Lower urinary tract symptoms (LUTS) and bladder afferent activity. Publishing Authors By Initials

N Yoshimura,N Yoshimura,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Lower urinary tract symptoms (LUTS) and bladder afferent activity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurourology and urodynamics

VOLUME: 26

Page Numbers: 908-13

Journal Abbreviation: Neurourol. Urodyn.

ISSN: 0733-2467

DAY: 26

MONTH: Oct

YEAR: 2007

Lower urinary tract symptoms (LUTS) and bladder afferent activity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8303326

Lower urinary tract symptoms (LUTS) and bladder afferent activity. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Lower urinary tract symptoms (LUTS) and bladder afferent activity. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Lower urinary tract symptoms (LUTS) and bladder afferent activity.

AFFILIATION: Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. nyos@pitt.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neurourol Urodyn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lower urinary tract symptoms LUTS and bladder afferent activity Related Publications

• A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3.
• A prospective study of green tea consumption and oral cancer incidence in Japan.
• Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.
• Characterization of wound drainage fluids as a source of soluble factors associated with wound healing: comparison with platelet-rich plasma and potential use in cell culture.
• Circadian clock genes and photoperiodism: Comprehensive analysis of clock gene expression in the mediobasal hypothalamus, the suprachiasmatic nucleus, and the pineal gland of Japanese Quail under various light schedules.
• Effects of IP-751, ajulemic acid, on bladder overactivity induced by bladder irritation in rats.
• Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats.
• Follow-up results of 71 patients undergoing metallic stent placement for the treatment of a malignant obstruction of the superior vena cava.
• Functional analysis of active urethral closure mechanisms under sneeze induced stress condition in a rat model of birth trauma.
• Further evidence that major outer membrane proteins homologous to OmpA in Porphyromonas gingivalis stabilize bacterial cells.
• Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury.
• Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation.
• Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.
• Inhibitory roles of peripheral nitrergic mechanisms in capsaicin-induced detrusor overactivity in the rat.
• Interobserver variation in the histopathological assessment of nonalcoholic steatohepatitis.
• Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols.
• Local effects of antimuscarinics.
• Lower urinary tract symptoms (LUTS) and bladder afferent activity.
• Mortality attributable to cigarette smoking in a cohort study in Japan.
• Neurophysiology of stress urinary incontinence.
• Novel mutations in the GRK1 gene in Japanese patients With Oguchi disease.
• Odor-intensity Coding in the Anterior Piriform Cortex.
• Polypoidal choroidal vasculopathy examined with en face optical coherence tomography.
• Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.
• Retinal pigment epithelial tear in polypoidal choroidal vasculopathy.
• Rice gibberellin-insensitive dwarf mutant gene Dwarf 1 encodes the alpha-subunit of GTP-binding protein.
• Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats.
• The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
• The effect of dendritic cells on the retinal cell transplantation.
• Torquetenovirus infection among northeastern Thai blood donors.