Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome.

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. Abstract Text:

Natia Kajaia,Helge Binder,Ralf Dittrich,Patricia G Oppelt,Bianca Flor,Susanne Cupisti,Matthias W Beckmann,Andreas Mueller,Natia Kajaia,Helge Binder,Ralf Dittrich,Patricia G Oppelt,Bianca Flor,Susanne Cupisti,Matthias W Beckmann,Andreas Mueller,

BACKGROUND: The aim of the present study is to assess insulin resistance (IR) in women with hyperandrogenic syndrome, which was suggested to replace the term polycystic ovary syndrome by the Androgen Excess Society, and to evaluate whether sex hormone-binding globulin (SHBG) can be used as a predictive marker of IR in hyperandrogenic women. METHODS: Clinical, metabolic, and endocrine parameters were measured, and an oral glucose tolerance test was carried out. The women were classified as IR group or non-IR group, in accordance with defined cutoff points for the homeostatic model assessment of IR (HOMA-IR) at > or =2.5, the quantitative insulin sensitivity check index at < or = 0.33, and the Matsuda insulin sensitivity index (ISI) at < or = 5. RESULTS: The women classified as having IR had a significantly higher body mass index (BMI) and free androgen index (FAI) and showed significantly lower SHBG and high-density lipoprotein (HDL) levels, regardless of the indices used. However, with the Matsuda ISI, generally more women were diagnosed as having IR, and this group had significantly higher total testosterone and triglyceride values, as well as a higher incidence of hirsutism. CONCLUSIONS: Women who were classified as being insulin resistant using insulin sensitivity indices showed significantly higher BMI and FAI values and lower SHBG and HDL levels. However, the Matsuda ISI may be more favorable for identifying IR in hyperandrogenic women. SHBG may serve as a predictive marker of IR in these women, particularly in those who are obese.

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. Publishing Authors By Initials

N Kajaia,H Binder,R Dittrich,PG Oppelt,B Flor,S Cupisti,MW Beckmann,A Mueller,N Kajaia,H Binder,R Dittrich,PG Oppelt,B Flor,S Cupisti,MW Beckmann,A Mueller,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of endocrinology / European Feder

VOLUME: 157

Page Numbers: 499-507

Journal Abbreviation: Eur. J. Endocrinol.

ISSN: 1479-683X

DAY: 25

MONTH: Oct

YEAR: 2007

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9423848

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome.

AFFILIATION: Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitaetsstrasse 21-23, D-91054 Erlangen, Germany.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Endocrinol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome Related Publications

• A case report of Clarkson's disease: If you don't know it, you'll miss it.
• Algorithms for on-line Differentiation of Neuroelectric Activities.
• Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells.
• An open trial of levetiracetam for segmental and generalized dystonia.
• Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.
• Dosage in the treatment of pollinosis.
• Effect of footwear and orthotic devices on stress reduction and soft tissue strain of the neuropathic foot.
• Exercise training and sympathetic nervous system activity: evidence for physical activity dependent neural plasticity.
• Exercise training attenuates increases in lumbar sympathetic nerve activity produced by stimulation of the rostral ventrolateral medulla.
• Lattice-based volumetric global illumination.
• Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome.
• Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.
• Molecular recognition of BMP-2 and BMP receptor IA.
• Non-catalytic function for ATR in the checkpoint response.
• Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase.
• Numerical simulation of the plantar pressure distribution in the diabetic foot during the push-off stance.
• Oleamide synthesizing activity from rat kidney: identification as cytochrome c.
• On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements.
• Pioglitazone: an anti-diabetic compound with anti-aging properties.
• Real-time 3D computed tomographic reconstruction using commodity graphics hardware.
• TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases.
• The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.
• The amide rotational barrier in isonicotinamide: Dynamic NMR and ab initio studies.
• The experience of rural independent pharmacies with medicare part D: reports from the field.
• The risk of malarial infections and disease in Papua New Guinean children.
• The use of B-type natriuretic peptides in the intensive care unit.
• Trace element removal during in vitro and in vivo continuous haemodialysis.
• Transcriptional dysregulation during myeloid transformation in AML.
• Vaccines against malaria - an update.
• Virus infection causes specific learning deficits in honeybee foragers.