Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic.

Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic. Research Abstract Details 

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Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic. Abstract Text:

Takao Iwai,Yoshifumi Harada,Koichi Imura,Sadahiro Iwabuchi,Junko Murai,Kunihiko Hiramatsu,Akira Myoui,Hideki Yoshikawa,Noriyuki Tsumaki,Takao Iwai,Yoshifumi Harada,Koichi Imura,Sadahiro Iwabuchi,Junko Murai,Kunihiko Hiramatsu,Akira Myoui,Hideki Yoshikawa,Noriyuki Tsumaki,

Synthetic porous ceramic made of hydroxyapatite (HA) has been used as a bone graft substitute. In the present study we investigated whether low-intensity pulsed ultrasound (LIPUS) accelerates bone ingrowth into the pores of HA ceramic. Application of LIPUS did not mechanically weaken porous ceramic that was immersed in water in vitro. In vivo experiments using rabbits showed that LIPUS application for 2 weeks significantly increased osteoblast number and bone area in the central part of the porous HA ceramic implanted in the femoral condyle in comparison with similarly implanted HA ceramic that was not exposed to LIPUS. LIPUS application for 3 weeks significantly increased mineralized tissue volume and mineral content in the porous HA ceramic. Wound healing assays revealed increased migration of MC3T3-E1 cells as a result of LIPUS treatment, partly accounting for the increased osteoblast number. Use of porous HA ceramic combined with LIPUS may be a promising treatment for filling large bone defects in a clinical setting.

Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic. Publishing Authors By Initials

T Iwai,Y Harada,K Imura,S Iwabuchi,J Murai,K Hiramatsu,A Myoui,H Yoshikawa,N Tsumaki,T Iwai,Y Harada,K Imura,S Iwabuchi,J Murai,K Hiramatsu,A Myoui,H Yoshikawa,N Tsumaki,

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Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of bone and mineral metabolism

VOLUME: 25

Page Numbers: 392-9

Journal Abbreviation: J. Bone Miner. Metab.

ISSN: 0914-8779

DAY: 25

MONTH: 10

YEAR: 2007

Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic. Information

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LANGUAGE: eng

NlmUniqueID: 9436705

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Grant and Affiliation Information for Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic.

AFFILIATION: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Country: Japan

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MEDLINETA: J Bone Miner Metab

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