Low dose nicotine treatment during early adolescence increases subsequent cocaine reward.

Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Research Abstract Details 

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Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Abstract Text:

Susan C McQuown,James D Belluzzi,Frances M Leslie,

Adolescence is a critical period for the initiation of drug use, starting with tobacco and alcohol and progressing to marijuana and other illicit drugs. These findings have led to the suggestion that tobacco and alcohol are 'gateway' drugs that sensitize maturing reward pathways to the effects of illicit substances such as cocaine. To test this hypothesis, we have examined whether low-dose nicotine pretreatment alters acquisition of cocaine self-administration in adolescents more than in adults. Male and female Sprague-Dawley rats, aged postnatal day (P) 28 or P86, were given two daily intravenous injections of nicotine (0.03 mg/kg/0.1 ml) or saline for 4 days. At P32 and P90, rats were placed in self-administration chambers and tested for acquisition of cocaine (0.2 or 0.5 mg/kg/inj) for 5 days. Data were collapsed across cocaine dose and sex since there was no significant effect of these variables. Adolescent rats pretreated with nicotine exhibited significantly greater cocaine-reinforced responding as compared to saline controls or adults (p<0.01). This drug pretreatment effect did not generalize to all rewards, since nicotine did not increase responding for sucrose pellets in adolescents. These findings provide evidence that the adolescent brain is uniquely vulnerable to the effects of nicotine on subsequent drug reward.

Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Publishing Authors By Initials

SC McQuown,JD Belluzzi,FM Leslie,

For similar therapeutics: drug therapy: self administration research abstracts see: therapeutics: drug therapy: self administration research

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Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurotoxicology and teratology

VOLUME: 29

Page Numbers: 66-73

Journal Abbreviation:

ISSN: 0892-0362

DAY: 14

MONTH: 12

YEAR: 2006

Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8709538

Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Keywords Mesh Terms:

KEYWORDS: Self Administration

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Information

Substance Name: Nicotine

Registry Number: 54-11-5

Grant and Affiliation Information for Low dose nicotine treatment during early adolescence increases subsequent cocaine reward.

AFFILIATION: Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA. smcquown@uci.edu

Country: United States

AGENCY: United States NIDA

GRANT: T32 DA007318-04

ACRONYM: DA

MEDLINETA: Neurotoxicol Teratol

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