Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo.

Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Research Abstract Details 

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Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Abstract Text:

J Nebe,M Heier,H C Diener,

A double-blind, threefold crossover, double-dummy trial was performed, investigating the efficacy of 200 mg ibuprofen compared with 500 mg acetylsalicylic acid and placebo in patients who usually treated their headaches with over-the-counter drugs. Ninety-five patients suffering from mild to moderate migraine or episodic tension-type headache were included. Seventy-seven patients entered the intention-to-treat analysis and 65 completed all three treatments. For the main response criterion, a minimum 50% decrease of headache intensity on a visual analogue scale at 1 h after treatment, ibuprofen was significantly superior to acetylsalicylic acid and placebo. This was true for migraine attacks and tension-type headache episodes. Towards the end of the observation period (150 min), the differences between ibuprofen and acetylsalicylic acid were no longer significant. In conclusion, ibuprofen was at least equivalent to acetylsalicylic acid and superior to placebo.

Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Publishing Authors By Initials

J Nebe,M Heier,HC Diener,

For similar therapeutics: drug therapy: self medication research abstracts see: therapeutics: drug therapy: self medication research

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Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cephalalgia : an international journal of headache

VOLUME: 15

Page Numbers: 531-5

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Dec

YEAR: 1995

Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8200710

Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Keywords Mesh Terms:

KEYWORDS: Self Medication

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Information

Substance Name: Aspirin

Registry Number: 50-78-2

Grant and Affiliation Information for Low-dose ibuprofen in self-medication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo.

AFFILIATION: Department of Neurology, University of Essen, Germany.

Country: NORWAY

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MEDLINETA: Cephalalgia

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