Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading.

Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Research Abstract Details 

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Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Abstract Text:

Leanne K Saxon,Charles H Turner,

Estrogen and exercise influence cortical bone formation. Both affect bone during growth, but with complex interactions. We hypothesized that estrogen reduces the osteogenic response caused by exercise at the periosteal surface of bone, while it enhances bone formation on the endocortical surface. To test our hypothesis, 16 young (8 weeks old) male Sprague-Dawley rats were randomized into two groups: (1) low-dose 17-alpha ethynylestradiol treatment+bone loading (EE2) or (2) vehicle-treated+bone loading (vehicle). We applied controlled loading to the right ulna at a peak force of 17 N, 2 min/day, 3 days/week for 5 weeks to simulate exercise. The left nonloaded ulna served as an internal control for loading. Mechanical loading increased cortical area (7.7%) and bone mineral content (8%) in the vehicle-treated group (P < 0.05) but only slightly increased cortical area in the EE2 group (P = 0.08). Histomorphometry showed 1 week of mechanical loading increased periosteal bone formation rate by 29% in the vehicle group and this response was reduced (P < 0.05) to only 15% in the EE2 group. At the endocortical surface, there were no differences in the loading response between the vehicle and EE2-treated groups. We conclude low-dose EE2 suppresses the mechanical loading response on the periosteal surface of long bones, but had no effect on the loading response at the endocortical bone surface in growing male rats.

Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Publishing Authors By Initials

LK Saxon,CH Turner,

For similar musculoskeletal system: skeleton: bone and bones: bones of upper extremity: arm bones: ulna research abstracts see: musculoskeletal system: skeleton: bone and bones: bones of upper extremity: arm bones: ulna research

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Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bone

VOLUME: 39

Page Numbers: 1261-7

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 24

MONTH: 08

YEAR: 2006

Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8504048

Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Keywords Mesh Terms:

KEYWORDS: Ulna

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Information

Substance Name: Ethinyl Estradiol

Registry Number: 57-63-6

Grant and Affiliation Information for Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading.

AFFILIATION: Department of Orthopaedic Surgery and Biomedical Engineering, IUPUI, Indianapolis, IN 46202, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR046530

ACRONYM: AR

MEDLINETA: Bone

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