Low-dose dexamethasone challenge in women with atypical major depression: pilot study.

Low-dose dexamethasone challenge in women with atypical major depression: pilot study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Low-dose dexamethasone challenge in women with atypical major depression: pilot study. Abstract Text:

OBJECTIVE: To examine if atypical depression may be associated with hypersuppression of the hypothalamic-pituitary-adrenal (HPA) axis. METHOD: Eight women with atypical major depression and 11 controls with no history of psychiatric illness, matched on age and body mass index, were challenged with low-dose dexamethasone (0.25 mg and 0.50 mg in random order and 1 week apart). Dexamethasone was self administered at 11 pm, and plasma cortisol samples were drawn at 8 am and 3 pm on the following day. RESULTS: After the 0.50-mg dexamethasone challenge, mean suppression of morning cortisol was significantly greater in patients with atypical depression (91.9%, standard deviation [SD] 6.8%) than in the controls (78.3%, SD 10.7%; p < 0.01). CONCLUSION: These preliminary data add to the growing body of literature that suggests atypical depression, in contrast to classic melancholia, may be associated with exaggerated negative feedback regulation of the HPA axis.

Low-dose dexamethasone challenge in women with atypical major depression: pilot study. Publishing Authors By Initials

For similar endocrine system: endocrine glands: pituitary-adrenal system research abstracts see: endocrine system: endocrine glands: pituitary-adrenal system research

PUBMED ID PMID:

MEDLINE DATE:

Low-dose dexamethasone challenge in women with atypical major depression: pilot study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 27

Page Numbers: 47-51

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: Jan

YEAR: 2002

Low-dose dexamethasone challenge in women with atypical major depression: pilot study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107859

Low-dose dexamethasone challenge in women with atypical major depression: pilot study. Keywords Mesh Terms:

KEYWORDS: Pituitary-Adrenal System

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Low-dose dexamethasone challenge in women with atypical major depression: pilot study. Information

Substance Name: Hydrocortisone

Registry Number: 50-23-7

Grant and Affiliation Information for Low-dose dexamethasone challenge in women with atypical major depression: pilot study.

AFFILIATION: Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont. Robert_Levitan@camh.net

Country: Canada

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Psychiatry Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Low-dose dexamethasone challenge in women with atypical major depression: pilot study Related Publications

• A capillary-PDMS hybrid chip for separations-based sensing of neurotransmitters in vivo.
• A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy.
• Allostasis: a theoretical framework for understanding and evaluating perinatal health outcomes.
• Attitudes of children towards peers with acquired brain injury (ABI).
• Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity.
• Commentary: controversies in reproductive medicine.
• Cortical electric response audiometry hearing threshold estimation: accuracy, speed, and the effects of stimulus presentation features.
• Effect of feed delivery fluctuations and feeding time on ruminal acidosis, growth performance, and feeding behavior of feedlot cattle.
• Evaluation of cancer chemopreventive agents using clones derived from a human prostate cancer cell line.
• Fc gamma receptors play a dominant role in protective tumor immunity against a virus-encoded tumor-specific antigen in a murine model of experimental pulmonary metastases.
• Fertility studies in young and mature merino ewes 1. Cervical mucus production.
• Fertility studies in young and mature merino ewes 2. Sperm transport.
• Genetic aspects of embryo transfer.
• Healthy lifestyles. healthy people - The Mega Country Health Promotion Network.
• Human cerebral cortex: a system for the integration of volume- and surface-based representations.
• Identification and quantification of neuropeptides in brain tissue by capillary liquid chromatography coupled off-line to MALDI-TOF and MALDI-TOF/TOF-MS.
• Metabolomic analysis of eukaryotic tissue and prokaryotes using negative mode MALDI time-of-flight mass spectrometry.
• Microdialysis coupled on-line to capillary liquid chromatography with tandem mass spectrometry for monitoring acetylcholine in vivo.
• Monitoring dopamine in vivo by microdialysis sampling and on-line CE-laser-induced fluorescence.
• Multiplexed detection of protein-peptide interaction and inhibition using capillary electrophoresis.
• NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein.
• Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells.
• Parasitic helminths: from genomes to vaccines.
• Peppers and poisons: the evolutionary ecology of bad taste.
• Prion protein genes in caribou from Alaska.
• Protective effects of L-selenomethionine on space radiation induced changes in gene expression.
• Recent developments in yeast aging.
• SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen.
• Serial immunoassays in parallel on a microfluidic chip for monitoring hormone secretion from living cells.
• The effect of selection for fertility of frozen-thawed semen on spermatozoa oxygen uptake, motility and concentration, and ejaculate volume in the chicken.