Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease.

Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. Research Abstract Details 

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Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. Abstract Text:

Duncan J Campbell,Bruce C Neal,John P Chalmers,Samuel A Colman,Alicia J Jenkins,Bruce E Kemp,Anushka Patel,Stephen W Macmahon,Mark Woodward,

BACKGROUND: Only limited data are available for risk factors for intracerebral haemorrhage (ICH) in subjects with established cerebrovascular disease. DESIGN: We performed a nested case-control study of participants of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS). This was a randomized, placebo-controlled trial that established the beneficial effects of blood pressure lowering in 6105 patients with cerebrovascular disease. METHODS: Each of 41 subjects who experienced ICH during a mean follow-up of 3.9 years was matched to 1-3 control subjects. Lipoprotein particles and other plasma markers were measured in baseline blood samples from PROGRESS participants. RESULTS: In comparison with control subjects, ICH cases had increased mean low-density lipoprotein (LDL) diameter (P=0.04) and increased large LDL particle concentration (P=0.03). The odds ratio (adjusted for regression dilution bias) for ICH risk with 10 mmHg increase in systolic blood pressure (SBP) was 1.45 (95% confidence interval: 1.01-2.09, P=0.05), with a 1 nm increase in mean LDL diameter it was 2.15 (95% confidence interval: 0.97-4.77, P=0.06), and with 100 nmol/l increase in large LDL particle concentration it was 1.18 (95% confidence interval: 0.98-1.43, P=0.08). Plasma levels of C-reactive protein (CRP), soluble vascular cell adhesion molecule 1 (sVCAM-1), homocysteine, amino-terminal-pro-B-type natriuretic peptide (NT-proBNP), and renin were not associated with ICH risk. CONCLUSION: SBP predicted ICH risk in subjects with cerebrovascular disease, whereas CRP, sVCAM-1, homocysteine, NT-proBNP, and renin did not predict ICH risk. The trends for prediction of ICH risk by mean LDL particle diameter and large LDL particle concentration are hypothesis generating and require confirmation in larger studies.

Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. Publishing Authors By Initials

DJ Campbell,BC Neal,JP Chalmers,SA Colman,AJ Jenkins,BE Kemp,A Patel,SW Macmahon,M Woodward,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: myocardial contraction: systole research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: myocardial contraction: systole research

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Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of cardiovascular prevention and

VOLUME: 14

Page Numbers: 413-8

Journal Abbreviation:

ISSN: 1741-8267

DAY: 3

MONTH: Jun

YEAR: 2007

Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101192000

Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. Keywords Mesh Terms:

KEYWORDS: Systole

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. Information

Substance Name: Perindopril

Registry Number: 82834-16-0

Grant and Affiliation Information for Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease.

AFFILIATION: St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. dcampbell@svi.edu.au

Country: England

AGENCY: United States NHLBI

GRANT: 5 R01 HL071685

ACRONYM: HL

MEDLINETA: Eur J Cardiovasc Prev Rehabil

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